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Also known as caspases

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue. As of 2009, there are 12 confirmed caspases in humans and 10 in mice, carrying out a variety of cellular functions.

Key facts

Protein family.Symbol: Peptidase_C14
Protein family.Name: Caspase domain
Protein family.image: Caspase 1.png
Protein family.caption: Structure of caspase-1 (CASP1), originally called interleukin-1 beta-converting enzyme (ICE), the first human caspase to be identified.
Protein family.Pfam: PF00656
Protein family.Pfam_clan: CL0093
Protein family.InterPro: IPR002398
Protein family.MEROPS: C14
Protein family.PROSITE: PS50208
Protein family.SCOP: 1ice