apoptosome
Sign in to savethumb|alt=3D structure of the human apoptosome-CARD complex.|3D structure of the human apoptosome-CARD complex. blue: apoptosome platform; magenta: CARD disk
Research
792 papers- Apoptosome: a platform for the activation of initiator caspases.Cell death and differentiation · 2007
- Apoptosome structure, assembly, and procaspase activation.Structure (London, England : 1993) · 2013
- Apoptosome: the seven-spoked death machine.Developmental cell · 2002
- New insights into apoptosome structure and function.Cell death and differentiation · 2018
- Apoptosome: the cellular engine for the activation of caspase-9.Structure (London, England : 1993) · 2002
via PubMed
Article
21 sectionsContents
- History
- Structure
- Detailed structural features
- Non-human organisms
- Mechanism of action
- Initiation
- Cytochrome c release
- Apaf-1
- Absence of cytochrome c
- Presence of cytochrome c
- Active action
- Research areas
- Mutations in the apoptosome pathway
- Repression of apoptosis and cancer
- P53 mutations in apoptosis
- Cancer therapy
- Bcl-2 as a therapeutic target
- Caspases and their role in therapy
- New potential targets for molecular therapy
- See also
- References
thumb|alt=3D structure of the human apoptosome-CARD complex.|3D structure of the human apoptosome-CARD complex. blue: apoptosome platform; magenta: CARD disk
The apoptosome is a quaternary protein structure formed in the process of apoptosis. It is formed by the release of cytochrome c from the mitochondrion responses to an internal (intrinsic) or external (extrinsic) cell death stimulus. Stimuli can differ from DNA damage or viral infection to developmental signals for instance like those leading to the degradation of a tadpole’s tail.