CBFA2T2

Name

CBFA2/RUNX1 partner transcriptional co-repressor 2

Type

protein-coding

Position

33,490,060–33,650,036 (+)

Aliases

EHT, MTGR1, ZMYND3, p85

Ensembl

ENSG00000078699

RefSeq RNA

NM_001032999.3, NM_001039709.2, NM_005093.4, NM_175864.1

RefSeq protein

NP_001028171.1, NP_001034798.1, NP_005084.1

In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

CBFA2/RUNX1 partner transcriptional co-repressor 2

Symbol

CBFA2T2

Biotype

Protein coding

Organism

Homo sapiens

Location

20:33,490,060-33,650,036

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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