DC-SIGN

Name

CD209 molecule

Type

protein-coding

Position

7,739,993–7,747,623 (−)

Aliases

CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, hDC-SIGN

Ensembl

ENSG00000090659

RefSeq RNA

NM_001144893.2, NM_001144894.2, NM_001144895.2, NM_001144896.2, NM_001144897.2

RefSeq protein

NP_001138365.1, NP_001138366.1, NP_001138367.1, NP_001138368.1, NP_001138369.1

This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity. [provided by RefSeq, May 2020].

via MyGene.info

Gene · Ensembl

CD209 molecule

Symbol

CD209

Biotype

Protein coding

Organism

Homo sapiens

Location

19:7,739,993-7,747,623

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein CD209 PDB 1k9i.png

via Wikidata · CC0