SIGLEC1

Also known as CD169, SIGLEC-1, SN, dJ1009E24.1, sialic acid binding Ig like lectin 1

Sialoadhesin (SIGLEC-1) is a cell adhesion molecule found on the surface of various immune cells. It is found in especially high amounts on macrophages of the spleen, liver, lymph node, bone marrow, colon, and lungs.

In the Vinony graph

Vinony's link graph records 395 inbound references to SIGLEC1, and connects out to CD1, SIGLEC and protein.

Vinony files it under Clusters of differentiation, Genes on human chromosome 20 and Siglec.

Vinony links it to 4 Wikipedia language editions.

Gene data

SIGLEC1

Name: sialic acid binding Ig like lectin 1
Type: protein-coding
Position: 3,686,970–3,712,647 (−)
Aliases: CD169, SIGLEC-1, SN
Ensembl: ENSG00000088827
RefSeq RNA: NM_001367089.1, NM_023068.4
RefSeq protein: NP_001354018.1, NP_075556.1

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and bacterial and viral infections has been shown to enhance SARS-CoV-2 infection. [provided by RefSeq, Dec 2021].

Gene Ontology

Biological process

inflammatory response cell-matrix adhesion negative regulation of type I interferon production clathrin-dependent endocytosis of virus by host cell cell-cell adhesion

Molecular function

carbohydrate binding virion binding

Cellular component

extracellular region early endosome late endosome plasma membrane plasma membrane plasma membrane membrane

Pathways

Cell adhesion molecules - Homo sapiens (human)Adaptive Immune System Immune System Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

via MyGene.info

Gene · Ensembl

sialic acid binding Ig like lectin 1

Symbol: SIGLEC1
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:3,686,970-3,712,647
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: 2BVE.pdb.jpg

Show 6 more facts

HomoloGene ID: 124458
exact match: identifiers.org/ncbigene/6614
genomic end: 3712600
genomic start: 3667617
cytogenetic location: 20p13
Commons category: Sialoadhesin

Sources (4)

via Wikidata · CC0

~2 min read

Encyclopedic overview

2 sections

Contents

Expression
References

Soluble SIGLEC-1 is a biomarker of monocyte-macrophage activation in systemic lupus erythematosus (SLE) and other autoimmune disorders. In patients with rheumatoid arthritis, the protein has been found in great amounts on macrophages of the affected tissues. It is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains), and thus also belongs to the immunoglobulin superfamily (IgSF).

Excerpted from Wikipedia’s “SIGLEC1” article, available under the CC BY-SA 4.0 licence.