Sialoadhesin (SIGLEC-1) is a cell adhesion molecule found on the surface of various immune cells. It is found in especially high amounts on macrophages of the spleen, liver, lymph node, bone marrow, colon, and lungs.
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and bacterial and viral infections has been shown to enhance SARS-CoV-2 infection. [provided by RefSeq, Dec 2021].
via MyGene.info
Sialoadhesin (SIGLEC-1) is a cell adhesion molecule found on the surface of various immune cells. It is found in especially high amounts on macrophages of the spleen, liver, lymph node, bone marrow, colon, and lungs.
Soluble SIGLEC-1 is a biomarker of monocyte-macrophage activation in systemic lupus erythematosus (SLE) and other autoimmune disorders. In patients with rheumatoid arthritis, the protein has been found in great amounts on macrophages of the affected tissues. It is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains), and thus also belongs to the immunoglobulin superfamily (IgSF).
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).