Toll like receptor 2

Protein · UniProt

Toll-like receptor 2

Gene

TLR2

Organism

Homo sapiens (Human)

Length

784 aa

Molecular mass

89,838 Da

Evidence

1: Evidence at protein level

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:17889651, PubMed:21078852). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble…

• PHASE1/PHASE2COMPLETED
  Phase 1/2 Study of Motolimod, Doxorubicin, and Durvalumab in Recurrent, Platinum-Resistant Ovarian CancerLudwig Institute for Cancer Research · NCT02431559
• PHASE1COMPLETED
  Hespecta Vaccination in HPV+ Tumors or Malignant LesionsLeiden University · NCT02821494
• COMPLETED
  Toll-like Receptor 2 Gene Polymorphism, Serum Cytokines and Susceptibility to Disease Severity or Treatment Response of Pulmonary TuberculosisChang Gung Memorial Hospital · NCT00772408
• PHASE2/PHASE3UNKNOWN
  Oral Vitamin D and Toll Like Receptor in Spondylitis TuberculosisHasanuddin University · NCT05376189
• PHASE2COMPLETED
  Placebo-Controlled Study to Evaluate the Safety and Efficacy of OPN-305 in Preventing Delayed Renal Graft FunctionOpsona Therapeutics Ltd. · NCT01794663
• PHASE1/PHASE2TERMINATED
  A Study of DSP-0509 in Patients With Advanced Solid Tumors to Determine the Safety and the Pharmacokinetic ProfileSumitomo Pharma America, Inc. · NCT03416335

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

Subclass of

toll-like receptor

Part of

Leucine-rich repeat, protein family

via Wikidata · CC0