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GeneQ18029067· pop 5· linked from 359 articles

MELTF

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Also known as CD228, MAP97, MTF1, MTf, MFI2, melanotransferrin

Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).

Gene data

MELTF
Name
melanotransferrin
Type
protein-coding
Position
196,980,590–197,029,874 (−)
Aliases
CD228, MAP97, MFI2, MTF1, MTf
Ensembl
ENSG00000163975
RefSeq RNA
NM_005929.6, NM_033316.4, XM_006713643.4, XM_011512850.3, XM_047448150.1
RefSeq protein
NP_005920.2, NP_201573.1, XP_006713706.2, XP_011511152.1, XP_047304106.1

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008].

Gene Ontology

Pathways

Post-translational modification: synthesis of GPI-anchored proteinsRegulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)Metabolism of proteinsPost-translational protein modificationPost-translational protein phosphorylation3q29 copy number variation syndrome

via MyGene.info

Gene · Ensembl

melanotransferrin

Symbol
MELTF
Biotype
Protein coding
Organism
Homo sapiens
Location
3:196,980,590-197,029,874
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

3 sections
Contents
  • References
  • Further reading
  • External links

Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. It is part of neural crest tissue, often present in melanotic neuroectodermal tumor of infancy.

Excerpted from Wikipedia’s “MELTF” article, available under the CC BY-SA 4.0 licence.

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