CD14 molecule
Sign in to saveAlso known as monocyte differentiation antigen CD14, CD14, myeloid cell-specific leucine-rich glycoprotein, Lipopolysaccharide Receptors
CD14 (cluster of differentiation 14) is a surface membrane protein made mostly by macrophages as part of the innate immune system. It helps to detect bacteria in the body by binding lipopolysaccharide (LPS), a pathogen-associated molecular pattern (PAMP). It is highly expressed on monocytes and macrophages, and at lower levels on neutrophils and dendritic cells.
Protein · UniProt
Monocyte differentiation antigen CD14
- Gene
- CD14
- Organism
- Homo sapiens (Human)
- Length
- 375 aa
- Molecular mass
- 40,076 Da
- Evidence
- 1: Evidence at protein level
Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:22265692, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipo…
Swiss-Prot (reviewed) · via UniProt
Research
21,303 papers- Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer.Immunity · 2017
- CD14.The international journal of biochemistry & cell biology · 1999
- Multifaceted role of CD14 in innate immunity and tissue homeostasis.Cytokine & growth factor reviews · 2023
- Inhibition of the complement component C5 and the Toll-like receptor molecule CD14 prevents systemic and local kidney inflammation in mice experiencing brain death.Scientific reports · 2025
- Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood.Journal of immunology (Baltimore, Md. : 1950) · 2019
via PubMed
~2 min read
Article
6 sectionsContents
- Function
- Tissue distribution
- Differentiation
- Interactions
- References
- External links
CD14 (cluster of differentiation 14) is a surface membrane protein made mostly by macrophages as part of the innate immune system. It helps to detect bacteria in the body by binding lipopolysaccharide (LPS), a pathogen-associated molecular pattern (PAMP). It is highly expressed on monocytes and macrophages, and at lower levels on neutrophils and dendritic cells.
CD14 exists in two forms, one anchored to the membrane by a glycosylphosphatidylinositol (GPI) tail (mCD14), the other a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 kDa) or is directly secreted from intracellular vesicles (56 kDa).