CD247
Sign in to saveAlso known as CD3-ZETA, CD3H, CD3Q, CD3Z, IMD25, T3Z, TCRZ, CD247 molecule
gene umano
Gene data
CD247- Name
- CD247 molecule
- Type
- protein-coding
- Position
- 167,425,027–167,518,640 (−)
- Aliases
- CD3-ZETA, CD3H, CD3Q, CD3Z, CD3ZETA, IMD25, T3Z, TCRZ
- Ensembl
- ENSG00000198821
- RefSeq RNA
- NM_000734.4, NM_001378515.1, NM_001378516.1, NM_198053.3, XM_011510144.3
- RefSeq protein
- NP_000725.1, NP_001365444.1, NP_001365445.1, NP_932170.1, XP_011508446.1
The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
Natural killer cell mediated cytotoxicity - Homo sapiens (human)Th1 and Th2 cell differentiation - Homo sapiens (human)Th17 cell differentiation - Homo sapiens (human)T cell receptor signaling pathway - Homo sapiens (human)Chagas disease - Homo sapiens (human)Epstein-Barr virus infection - Homo sapiens (human)Human immunodeficiency virus 1 infection - Homo sapiens (human)PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)Adaptive Immune SystemHIV Infection
via MyGene.info
Gene · Ensembl
CD247 molecule
- Symbol
- CD247
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:167,425,027-167,518,640
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CD247 PDB 2hac.png
Show 7 more facts
- found in taxon
- Homo sapiens
- HomoloGene ID
- 12818
- chromosome
- human chromosome 1
- exact match
- identifiers.org/ncbigene/919
- genomic end
- 167487847
- genomic start
- 167399877
- cytogenetic location
- 1q24.2
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