CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell-antigen interactions.
Key facts
- Protein family.Symbol
- CD8
- Protein family.Name
- Putative T-cell surface glycoprotein CD8
- Protein family.caption
- Crystallographic structure of the extracellular domain of CD8 molecule.
- Protein family.Membranome family
- 29
- Protein.Name
- CD8b molecule
- Protein.HGNCid
- 1707
- Protein.Symbol
- CD8B
- Protein.AltSymbols
- CD8B1
- Protein.EntrezGene
- 925
- Protein.OMIM
- 186910
- Protein.RefSeq
- NM_001768
- Protein.UniProt
- P01732
- Protein.Chromosome
- 2
- Protein.Arm
- p
- Protein.Band
- 12
via Wikipedia infobox
Article
5 sectionsContents
- Tissue distribution
- Structure of the CD8 complexes
- Function
- References
- External links
CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell-antigen interactions.
Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the MHC class I protein. However, while the TCR interacts with the antigen-binding region of MHC-I, the CD8 molecule binds to the α3 domain, a non-variant region of MHC-I located away from the antigen-binding site.