CDC42EP1

Also known as BORG5, CEP1, MSE55, CDC42 effector protein 1

Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene.

Gene data

CDC42EP1

Name: CDC42 effector protein 1
Type: protein-coding
Position: 37,555,112–37,569,764 (+)
Aliases: BORG5, CEP1, MSE55
Ensembl: ENSG00000128283
RefSeq RNA: NM_152243.3
RefSeq protein: NP_689449.1

CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. This protein is secreted and is primarily found in bone marrow. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

Rho protein signal transduction regulation of cell shape regulation of cell shape positive regulation of actin filament polymerization positive regulation of pseudopodium assembly positive regulation of pseudopodium assembly cell-cell adhesion

Molecular function

protein binding small GTPase binding cadherin binding involved in cell-cell adhesion

Cellular component

cytoplasm cytoplasm cytosol cytoskeleton cytoskeleton plasma membrane plasma membrane adherens junction

Pathways

Signal Transduction Signaling by Rho GTPases RHO GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle

via MyGene.info

Wikidata facts

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HomoloGene ID: 5128
exact match: identifiers.org/ncbigene/11135
genomic start: 37560480
genomic end: 37965412
cytogenetic location: 22q13.1

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Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene.

CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. The encoded protein, which is secreted, is primarily found in bone marrow. Two transcript variants encoding different isoforms have been found for this gene.