CDC34
Sign in to saveAlso known as E2-CDC34, UBC3, UBCH3, UBE2R1, cell division cycle 34, cell division cycle 34, ubiqiutin conjugating enzyme
CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1. This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment of ubiquitin to other proteins.
Gene data
CDC34- Name
- cell division cycle 34, ubiquitin conjugating enzyme
- Type
- protein-coding
- Aliases
- E2-CDC34, UBC3, UBCH3, UBE2R1
The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
cell division cycle 34, ubiquitin conjugating enzyme
- Symbol
- CDC34
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:531,435-542,092
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- External links
- Further reading
CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1. This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment of ubiquitin to other proteins.
CDC34 was originally discovered by work in baker's yeast as a gene that is essential for the cell cycle. Cdc34 in yeast targets numerous substrates - notably the cyclin-dependent kinase inhibitor Sic1 - for ubiquitin-mediated protein degradation. CDC34 is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.
Excerpted from Wikipedia’s “CDC34” article, available under the CC BY-SA 4.0 licence.