CHMP2A

Also known as BC-2, BC2, CHMP2, VPS2, VPS2A, charged multivesicular body protein 2A

Charged multivesicular body protein 2a is a protein that in humans is encoded by the CHMP2A gene. It is a reference gene.

In the Vinony graph

Within Vinony's link graph, CHMP2A is referenced by 3 other articles, and connects out to PubMed, human chromosome 19 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 19.

Its subject is documented across 6 Wikipedia language editions.

Gene data

CHMP2A

Name: charged multivesicular body protein 2A
Type: protein-coding
Position: 58,551,452–58,555,129 (−)
Aliases: BC-2, BC2, CHMP2, VPS2, VPS2A
Ensembl: ENSG00000130724
RefSeq RNA: NM_014453.4, NM_198426.3, XM_005258746.3, XM_005258747.4, XM_054320574.1
RefSeq protein: NP_055268.1, NP_940818.1, XP_005258803.1, XP_005258804.1, XP_054176549.1

CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008].