cholera toxin
Sign in to saveAlso known as ctx
protein complex secreted by the bacterium Vibrio cholerae
Protein · UniProt
Cholera enterotoxin subunit A
- Gene
- ctxA
- Organism
- Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
- Length
- 258 aa
- Molecular mass
- 29,336 Da
- Evidence
- 1: Evidence at protein level
The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring
3D-structureDirect protein sequencingDisulfide bondEnterotoxinGlycosyltransferaseNADNucleotidyltransferaseReference proteome
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Research
15,310 papers- Cholera toxin.Bioscience reports · 1982
- Cholera toxin.Biological reviews of the Cambridge Philosophical Society · 1977
- Vibrio cholerae: cholera toxin.The international journal of biochemistry & cell biology · 2007
- Advances in phage display based nano immunosensors for cholera toxin.Frontiers in immunology · 2023
- Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum.Toxins · 2010
via PubMed
Wikidata facts
- Instance of
- protein complex
Show 3 more facts
- Commons category
- Cholera toxin
- subject has role
- poison
- found in taxon
- Vibrio cholerae
Sources (2)
via Wikidata · CC0