B3GAT1

Also known as CD57, GLCATP, GLCUATP, HNK1, LEU7, NK-1, NK1, beta-1,3-glucuronyltransferase 1

3-beta-glucuronosyltransferase 1 (B3GAT1) is an enzyme that in humans is encoded by the B3GAT1 gene, whose enzymatic activity creates the CD57 epitope on other cell surface proteins. In immunology, the CD57 antigen (CD stands for cluster of differentiation) is also known as HNK1 (human natural killer-1) or LEU7. It is expressed as a carbohydrate epitope that contains a residue in several adhesion molecules of the nervous system.

Gene data

B3GAT1

Name: beta-1,3-glucuronyltransferase 1
Type: protein-coding
Position: 134,378,504–134,412,250 (−)
Aliases: CD57, GLCATP, GLCUATP, HNK1, LEU7, NK-1, NK1
Ensembl: ENSG00000109956
RefSeq RNA: NM_001367973.1, NM_018644.3, NM_054025.3, XM_011542753.3, XM_017017551.3
RefSeq protein: NP_001354902.1, NP_061114.2, NP_473366.1, XP_011541055.1, XP_016873040.1

The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].