B3GAT1
Sign in to saveAlso known as CD57, GLCATP, GLCUATP, HNK1, LEU7, NK-1, NK1, beta-1,3-glucuronyltransferase 1
3-beta-glucuronosyltransferase 1 (B3GAT1) is an enzyme that in humans is encoded by the B3GAT1 gene, whose enzymatic activity creates the CD57 epitope on other cell surface proteins. In immunology, the CD57 antigen (CD stands for cluster of differentiation) is also known as HNK1 (human natural killer-1) or LEU7. It is expressed as a carbohydrate epitope that contains a residue in several adhesion molecules of the nervous system.
In the Vinony graph
Within Vinony's link graph, B3GAT1 is referenced by 777 other articles, and connects out to glucuronosyltransferase, PubMed and lymphocyte.
It sits within the topics Clusters of differentiation and Genes on human chromosome 11.
Its subject is documented across 5 Wikipedia language editions.
Gene data
B3GAT1- Name
- beta-1,3-glucuronyltransferase 1
- Type
- protein-coding
- Position
- 134,378,504–134,412,250 (−)
- Aliases
- CD57, GLCATP, GLCUATP, HNK1, LEU7, NK-1, NK1
- Ensembl
- ENSG00000109956
- RefSeq RNA
- NM_001367973.1, NM_018644.3, NM_054025.3, XM_011542753.3, XM_017017551.3
- RefSeq protein
- NP_001354902.1, NP_061114.2, NP_473366.1, XP_011541055.1, XP_016873040.1
The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
beta-1,3-glucuronyltransferase 1
- Symbol
- B3GAT1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:134,378,504-134,412,250
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein B3GAT1 PDB 1v82.png
Show 7 more facts
- HomoloGene ID
- 49551
- exact match
- identifiers.org/ncbigene/27087
- found in taxon
- Homo sapiens
- genomic end
- 134412242
- genomic start
- 134248398
- chromosome
- human chromosome 11
- cytogenetic location
- 11q25
Sources (4)
via Wikidata · CC0
~3 min read
Encyclopedic overview
5 sectionsContents
- Function
- Immunohistochemistry
- References
- Further reading
- External links
3-beta-glucuronosyltransferase 1 (B3GAT1) is an enzyme that in humans is encoded by the B3GAT1 gene, whose enzymatic activity creates the CD57 epitope on other cell surface proteins. In immunology, the CD57 antigen (CD stands for cluster of differentiation) is also known as HNK1 (human natural killer-1) or LEU7. It is expressed as a carbohydrate epitope that contains a residue in several adhesion molecules of the nervous system.
== Function ==
Excerpted from Wikipedia’s “B3GAT1” article, available under the CC BY-SA 4.0 licence.