cisplatin

Also known as Platinol, CIS-DDP, Platinol-AQ, CDDP, cis-diamminedichloroplatinum(II), Cis-DDP

Cisplatin is a chemical compound with formula cis-. It is a coordination complex of platinum that is used as a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein.

Key facts

Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 457790642
Drug.IUPAC_name: (SP-4-2)-diamminedichloridoplatinum(II)
Drug.image: CisplatinTR.svg
Drug.image_class: skin-invert-image
Drug.image2: Cisplatin-3D-balls.png
Drug.image_class2: bg-transparent
Drug.tradename: Platinol, others
Drug.synonyms: Cisplatinum, platamin, neoplatin, cismaplat, cis-diamminedichloroplatinum(II) (CDDP)
Drug.MedlinePlus: a684036
Drug.DailyMedID: Cisplatin
Drug.pregnancy_AU: D
Drug.pregnancy_US: N
Drug.pregnancy_category: Contraindicated
Drug.legal_AU: S4
Drug.legal_CA: Rx-only
Drug.legal_UK: POM

via Wikipedia infobox

Chemical data

Formula: Cl2H6N2Pt
Molecular weight: 300.05 g/mol
IUPAC name: azane;dichloroplatinum
SMILES: N.N.Cl[Pt]Cl
InChIKey: LXZZYRPGZAFOLE-UHFFFAOYSA-L
Polar surface area: 2 Å²
H-bond donors: 2
H-bond acceptors: 2
Formal charge: 0

via PubChem

Research

98,633 papers

Cisplatin.Cancer chemotherapy and biological response modifiers · 1992
Cisplatin-based combination therapies: Their efficacy with a focus on ginsenosides co-administration.Pharmacological research · 2024
Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer.Cell reports. Medicine · 2024
Cisplatin Chemotherapy and Cochlear Damage: Otoprotective and Chemosensitization Properties of Polyphenols.Antioxidants & redox signaling · 2022
Management of cisplatin-associated toxicities in bladder cancer patients.Current opinion in supportive and palliative care · 2020

via PubMed

Wikidata facts

Mass: 298.955595

Show 5 more facts

chemical formula: Cl₂H₆N₂Pt
canonical SMILES: Cl[Pt]([NH3])([NH3])Cl
Commons category: Cisplatin
stylized name: CISplatin
isomeric SMILES: Cl[Pt@SP1]([NH3])([NH3])Cl

Sources (8)

via Wikidata · CC0

~13 min read

Article

12 sections

Contents

Medical use
Side effects
Pharmacology
Cisplatin resistance
Transplatin
Molecular structure
History
Synthesis
Research
References
Further reading
External links

Common side effects include bone marrow suppression, hearing problems including severe hearing loss, kidney damage, and vomiting. Other serious side effects include numbness, trouble walking, allergic reactions, electrolyte problems, and heart disease. Use during pregnancy can cause harm to the developing fetus. Cisplatin is in the platinum-based antineoplastic family of medications. It works in part by binding to DNA and inhibiting its replication.