Structure via PubChem · Public domain (PubChem)
carboplatin
Sign in to saveAlso known as JM-8, Paraplatin, cis-Diammine(1,1-cyclobutanedicarboxylato)platinum, cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II), cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(ii), CBDCA
Carboplatin, sold under the brand name Paraplatin among others, is a chemotherapy medication used to treat a number of forms of cancer. This includes ovarian cancer, lung cancer, head and neck cancer, brain cancer, and neuroblastoma. It is administered by injection into a vein sometimes via a port.
Key facts
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 460018795
- Drug.image
- Carboplatin-skeletal.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Carboplatin-from-xtal-view-1-Mercury-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Paraplatin, others
- Drug.MedlinePlus
- a695017
- Drug.routes_of_administration
- Intravenous
- Drug.ATC_prefix
- L01
- Drug.ATC_suffix
- XA02
- Drug.ATC_supplemental
- ]
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_status
- Rx-only
- Drug.bioavailability
- complete
- Drug.protein_bound
- Very low
- Drug.elimination_half life
- 1.1-2 hours
via Wikipedia infobox
Chemical data
- Formula
- C6H12N2O4Pt
- Molecular weight
- 371.25 g/mol
- IUPAC name
- azane;cyclobutane-1,1-dicarboxylate;platinum(2+)
- SMILES
- C1CC(C1)(C(=O)[O-])C(=O)[O-].N.N.[Pt+2]
- InChIKey
- OLESAACUTLOWQZ-UHFFFAOYSA-L
- Polar surface area
- 82.3 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Wikidata facts
- Mass
- 371.044
Show 5 more facts
- chemical formula
- C₆H₁₂N₂O₄Pt
- Commons category
- Carboplatin
- canonical SMILES
- O=C1O[Pt]23OC(=O)C11CCC1.[NH3]2.[NH3]3
- NCI Thesaurus ID
- C1282
- stylized name
- CARBOplatin
Sources (9)
via Wikidata · CC0
~6 min read
Article
8 sectionsContents
- Medical uses
- Side effects
- Mechanism of action
- Dose calculation using Calvert's equation
- Synthesis
- History
- References
- Further reading
Carboplatin, sold under the brand name Paraplatin among others, is a chemotherapy medication used to treat a number of forms of cancer. This includes ovarian cancer, lung cancer, head and neck cancer, brain cancer, and neuroblastoma. It is administered by injection into a vein sometimes via a port.
Side effects generally occur. Common side effects include low blood cell levels, nausea, and electrolyte problems. Other serious side effects include allergic reactions and mutagenesis. It may be carcinogenic, but further research is needed to confirm this. Use during pregnancy may result in harm to the baby. Carboplatin is in the platinum-based antineoplastic family of medications and works by interfering with duplication of DNA.