mitoxantrone

Also known as CL-232315, Novantrone®, Mitoxantrona, Mitoxantronum, 1,4-DIHYDROXY-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-anthracenedione

Mitoxantrone (INN, BAN, USAN; also known as Mitozantrone in Australia; trade name Novantrone) is an anthracenedione antineoplastic agent.

Chemical data

Formula: C22H28N4O6
Molecular weight: 444.5 g/mol
IUPAC name: 1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione
SMILES: C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO
InChIKey: KKZJGLLVHKMTCM-UHFFFAOYSA-N
XLogP: 1
Polar surface area: 163 Å²
H-bond donors: 8
H-bond acceptors: 10
Formal charge: 0

via PubChem

Research

7,050 papers

Mitoxantrone.Drug intelligence & clinical pharmacy · 1986
Mitoxantrone, More than Just Another Topoisomerase II Poison.Medicinal research reviews · 2016
Mitoxantrone-Surfactant Interactions: A Physicochemical Overview.Molecules (Basel, Switzerland) · 2016
Mitoxantrone: a novel anthracycline derivative.Clinical pharmacy · 1988
[Mitoxantrone].Neurologia (Barcelona, Spain) · 2003

via PubMed

Wikidata facts

Mass: 444.201

Show 5 more facts

World Health Organisation international non-proprietary name: mitoxantron
chemical formula: C₂₂H₂₈N₄O₆
canonical SMILES: C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO
Commons category: Mitoxantrone
stylized name: mitoXANTRONE

Sources (7)

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Article

6 sections

Contents

Uses
Side effects
Mechanism of action
See also
References
External links

Mitoxantrone (INN, BAN, USAN; also known as Mitozantrone in Australia; trade name Novantrone) is an anthracenedione antineoplastic agent.

==Uses== Mitoxantrone is used to treat certain types of cancer, mostly acute myeloid leukemia. It improves the survival rate of children suffering from acute lymphoblastic leukemia relapse.