Structure via PubChem · Public domain (PubChem)
mitoxantrone
Sign in to saveAlso known as CL-232315, Novantrone®, Mitoxantrona, Mitoxantronum, 1,4-DIHYDROXY-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-anthracenedione
Mitoxantrone (INN, BAN, USAN; also known as Mitozantrone in Australia; trade name Novantrone) is an anthracenedione antineoplastic agent.
Chemical data
- Formula
- C22H28N4O6
- Molecular weight
- 444.5 g/mol
- IUPAC name
- 1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione
- SMILES
- C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO
- InChIKey
- KKZJGLLVHKMTCM-UHFFFAOYSA-N
- XLogP
- 1
- Polar surface area
- 163 Ų
- H-bond donors
- 8
- H-bond acceptors
- 10
- Formal charge
- 0
via PubChem
Research
7,050 papers- Mitoxantrone.Drug intelligence & clinical pharmacy · 1986
- Mitoxantrone, More than Just Another Topoisomerase II Poison.Medicinal research reviews · 2016
- Mitoxantrone-Surfactant Interactions: A Physicochemical Overview.Molecules (Basel, Switzerland) · 2016
- Mitoxantrone: a novel anthracycline derivative.Clinical pharmacy · 1988
- [Mitoxantrone].Neurologia (Barcelona, Spain) · 2003
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Has part
- hydrogen
- Mass
- 444.201
- Has use
- medication
Show 8 more facts
- World Health Organisation international non-proprietary name
- mitoxantron
- chemical formula
- C₂₂H₂₈N₄O₆
- route of administration
- intraperitoneal injection
- medical condition treated
- lymphoma
- canonical SMILES
- C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO
- Commons category
- Mitoxantrone
- stylized name
- mitoXANTRONE
- legal status (medicine)
- boxed warning
Sources (7)
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Uses
- Side effects
- Mechanism of action
- See also
- References
- External links
Mitoxantrone (INN, BAN, USAN; also known as Mitozantrone in Australia; trade name Novantrone) is an anthracenedione antineoplastic agent.
==Uses== Mitoxantrone is used to treat certain types of cancer, mostly acute myeloid leukemia. It improves the survival rate of children suffering from acute lymphoblastic leukemia relapse.
Excerpted from Wikipedia’s “mitoxantrone” article, available under the CC BY-SA 4.0 licence.