クラスリン
Sign in to saveAlso known as clathrin, GO:0071439, clathrin complex family, clathrin triskelion, Clathrin
Clathrin is a protein that plays a role in the formation of coated vesicles. Clathrin was first isolated by Barbara Pearse in 1976. It forms a triskelion shape composed of three clathrin heavy chains and three light chains. When the triskelia interact they form a polyhedral lattice that surrounds the vesicle. The protein's name refers to this lattice structure, deriving from Latin clathri, meaning lattice. Barbara Pearse named the protein clathrin at the suggestion of Graeme Mitchison, selecting it from three possible options. Coat-proteins, like clathrin, are used to build small vesicles in o
Key facts
- Protein family.class
- collapsible
- Protein family.Symbol
- Clathrin_lg_ch
- Protein family.Name
- Clathrin light chain
- Protein family.image
- PDB 1b89 EBI.jpg
- Protein family.caption
- clathrin heavy chain proximal repeat (linker)
- Protein family.Pfam
- PF01086
- Protein family.Pfam_clan
- CL0020
- Protein family.InterPro
- IPR000996
- Protein family.SCOP
- 3iyv
- Protein family.SMART
- SM00299
- Protein family.PROSITE
- PDOC00196
- Protein family.CATH
- 1b89
- Protein.name
- Clathrin light chain a
- Protein.bodyclass
- collapsible collapsed
- Protein.Symbol
- CLTCL1
- Protein.EntrezGene
- 8218
- Protein.HGNCid
- 2093
- Protein.UniProt
- P53675
via Wikipedia infobox
Research
3,850 papers- Regulation of Clathrin-Mediated Endocytosis.Annual review of biochemistry · 2018
- Molecular mechanism and physiological functions of clathrin-mediated endocytosis.Nature reviews. Molecular cell biology · 2011
- Clathrin-dependent endocytosis.The Biochemical journal · 2004
- Clathrin-containing adhesion complexes.The Journal of cell biology · 2019
- Clathrin and adaptors.Biochimica et biophysica acta · 1998
via PubMed
Wikidata facts
Show 2 more facts
- exact match
- purl.obolibrary.org/obo/GO_0071439
- Commons category
- Clathrin
Sources (3)
via Wikidata · CC0
Article · 日本語
クラスリン (clathrin) は細胞外マトリクスの分子がエンドサイトーシスにより取り込まれる際に形成される、エンドソーム外側を形作る骨格となるタンパク質である。クラスリン分子は三脚巴構造 (triskelion) を取り、エンドソーム形成時は、複数のクラスリンが重合して格子を作り、サッカーボールの様な構造を形作る。 細胞分裂中期においては、有糸分裂紡錘体の動原体繊維（正確には微小管もしくは微小管結合タンパク質）と結合し、動原体繊維の配向を制御している。さらに、p53タンパク質と結合し、p53の転写活性化能を制御すると報告されている。
Abstract from DBpedia / Wikipedia · CC BY-SA