格形蛋白
Sign in to saveAlso known as clathrin, GO:0071439, clathrin complex family, clathrin triskelion, Clathrin
Clathrin is a protein that plays a role in the formation of coated vesicles. Clathrin was first isolated by Barbara Pearse in 1976. It forms a triskelion shape composed of three clathrin heavy chains and three light chains. When the triskelia interact they form a polyhedral lattice that surrounds the vesicle. The protein's name refers to this lattice structure, deriving from Latin clathri, meaning lattice. Barbara Pearse named the protein clathrin at the suggestion of Graeme Mitchison, selecting it from three possible options. Coat-proteins, like clathrin, are used to build small vesicles in o
Key facts
- Protein family.class
- collapsible
- Protein family.Symbol
- Clathrin_lg_ch
- Protein family.Name
- Clathrin light chain
- Protein family.image
- PDB 1b89 EBI.jpg
- Protein family.caption
- clathrin heavy chain proximal repeat (linker)
- Protein family.Pfam
- PF01086
- Protein family.Pfam_clan
- CL0020
- Protein family.InterPro
- IPR000996
- Protein family.SCOP
- 3iyv
- Protein family.SMART
- SM00299
- Protein family.PROSITE
- PDOC00196
- Protein family.CATH
- 1b89
- Protein.name
- Clathrin light chain a
- Protein.bodyclass
- collapsible collapsed
- Protein.Symbol
- CLTCL1
- Protein.EntrezGene
- 8218
- Protein.HGNCid
- 2093
- Protein.UniProt
- P53675
via Wikipedia infobox
Research
3,850 papers- Regulation of Clathrin-Mediated Endocytosis.Annual review of biochemistry · 2018
- Molecular mechanism and physiological functions of clathrin-mediated endocytosis.Nature reviews. Molecular cell biology · 2011
- Clathrin-dependent endocytosis.The Biochemical journal · 2004
- Clathrin-containing adhesion complexes.The Journal of cell biology · 2019
- Clathrin and adaptors.Biochimica et biophysica acta · 1998
via PubMed
Wikidata facts
Show 2 more facts
- exact match
- purl.obolibrary.org/obo/GO_0071439
- Commons category
- Clathrin
Sources (3)
via Wikidata · CC0
Article · 中文
网格蛋白（英語：clathrin），又稱格形蛋白，是一種在細胞囊泡外側的蛋白質，最早於1976年由英國生物學家分離與命名。网格蛋白呈三曲枝狀，由三個重鏈與三個輕鏈組成，並可進一步組成多面體。网格蛋白的英文名來自拉丁文的clathratus，意指網格。如网格蛋白的包被蛋白是一些小膜泡的组成部分，用于在细胞内运输分子。膜泡的内吞和胞吐使细胞能够进行交流，转移营养物质，输入信号分子，在对细胞外环境进行采样后介导免疫反应，并清理组织炎症留下的细胞碎片。由网格蛋白或其类似蛋白介导的内吞途径可以被病毒和其他病原体劫持用于进入细胞。
Abstract from DBpedia / Wikipedia · CC BY-SA