Structure via PubChem · Public domain (PubChem)
clioquinol
Sign in to saveAlso known as Domeform-HC, Quin-O-Creme, Vioform, Chloroiodoquin, 5-chloro-7-iodoquinolin-8-ol, Iodochloroxyquinoline, Iodochlorhydroxyquin, 7-Iodo-5-chloroxine
Clioquinol (iodochlorhydroxyquin) tradename Entero-Vioform is an antifungal drug and antiprotozoal drug. It is neurotoxic in large doses. It is a member of a family of drugs called hydroxyquinolines which inhibit certain enzymes related to DNA replication. The drugs have been found to have activity against both viral and protozoal infections.
Chemical data
- Formula
- C9H5ClINO
- Molecular weight
- 305.5 g/mol
- IUPAC name
- 5-chloro-7-iodoquinolin-8-ol
- SMILES
- C1=CC2=C(C(=C(C=C2Cl)I)O)N=C1
- InChIKey
- QCDFBFJGMNKBDO-UHFFFAOYSA-N
- XLogP
- 3.5
- Polar surface area
- 33.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1934
- Admin. routes
- topical
- Indications
- chronic lymphocytic leukemia, Hodgkins lymphoma, myelodysplastic syndrome, acute myeloid leukemia
via ChEMBL · EBI
Research
1,294 papers- Clioquinol: To harm or heal.Pharmacology & therapeutics · 2019
- Feasibility of Repurposing Clioquinol for Cancer Therapy.Recent patents on anti-cancer drug discovery · 2020
- The toxicology of Clioquinol.Toxicology letters · 2008
- Clioquinol for the treatment of Alzheimer's Disease.The Cochrane database of systematic reviews · 2006
- Antimicrobial activity of clioquinol and nitroxoline: a scoping review.Archives of microbiology · 2022
via PubMed
Wikidata facts
- Mass
- 304.91
- Has use
- medication
Show 6 more facts
- chemical formula
- C₉H₅ClINO
- medical condition treated
- skin infection
- canonical SMILES
- C1=CC2=C(C(=C(C=C2Cl)I)O)N=C1
- World Health Organisation international non-proprietary name
- clioquinol
- Commons category
- Clioquinol
- subject has role
- allergen
via Wikidata · CC0
~5 min read
Encyclopedic overview
8 sectionsContents
- Antiprotozoal use
- Subacute myelo-optic neuropathy
- Topical use
- Potential use as a preventive or treatment in prostate cancer
- Use in neurodegenerative diseases
- Continued use and manufacture around the world
- See also
- References
Clioquinol (iodochlorhydroxyquin) tradename Entero-Vioform is an antifungal drug and antiprotozoal drug. It is neurotoxic in large doses. It is a member of a family of drugs called hydroxyquinolines which inhibit certain enzymes related to DNA replication. The drugs have been found to have activity against both viral and protozoal infections.
==Antiprotozoal use==
Excerpted from Wikipedia’s “clioquinol” article, available under the CC BY-SA 4.0 licence.
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via Wikidata sitelinks · CC0