clioquinol

Also known as Domeform-HC, Quin-O-Creme, Vioform, Chloroiodoquin, 5-chloro-7-iodoquinolin-8-ol, Iodochloroxyquinoline, Iodochlorhydroxyquin, 7-Iodo-5-chloroxine

Clioquinol (iodochlorhydroxyquin) tradename Entero-Vioform is an antifungal drug and antiprotozoal drug. It is neurotoxic in large doses. It is a member of a family of drugs called hydroxyquinolines which inhibit certain enzymes related to DNA replication. The drugs have been found to have activity against both viral and protozoal infections.

Research

1,294 papers

Clioquinol: To harm or heal.Pharmacology & therapeutics · 2019
Feasibility of Repurposing Clioquinol for Cancer Therapy.Recent patents on anti-cancer drug discovery · 2020
The toxicology of Clioquinol.Toxicology letters · 2008
Clioquinol for the treatment of Alzheimer's Disease.The Cochrane database of systematic reviews · 2006
Antimicrobial activity of clioquinol and nitroxoline: a scoping review.Archives of microbiology · 2022

via PubMed

Wikidata facts

Mass: 304.91
Has use: medication

Show 6 more facts

chemical formula: C₉H₅ClINO
medical condition treated: skin infection
canonical SMILES: C1=CC2=C(C(=C(C=C2Cl)I)O)N=C1
World Health Organisation international non-proprietary name: clioquinol
Commons category: Clioquinol
subject has role: allergen

Sources (3)

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Encyclopedic overview

8 sections

Contents

Antiprotozoal use
Subacute myelo-optic neuropathy
Topical use
Potential use as a preventive or treatment in prostate cancer
Use in neurodegenerative diseases
Continued use and manufacture around the world
See also
References

==Antiprotozoal use==

Excerpted from Wikipedia’s “clioquinol” article, available under the CC BY-SA 4.0 licence.

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