COIL
Sign in to saveAlso known as C79982, Cln80, p80, p80-coilin, coilin
Coilin is a protein that in humans is encoded by the COIL gene. Coilin got its name from the coiled shape of the Cajal bodies in which it is found. It was first identified using human autoimmune serum.
Gene data
COIL- Name
- coilin
- Type
- protein-coding
- Position
- 56,938,198–56,961,110 (−)
- Aliases
- CLN80, p80-coilin
- Ensembl
- ENSG00000121058
- RefSeq RNA
- NM_004645.3
- RefSeq protein
- NP_004636.1
The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
coilin
- Symbol
- COIL
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:56,938,198-56,961,110
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 3413
- genomic end
- 56961050
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8161
- genomic start
- 56938199
- chromosome
- human chromosome 17
- cytogenetic location
- 17q22
- expressed in
- urethra
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
Coilin is a protein that in humans is encoded by the COIL gene. Coilin got its name from the coiled shape of the Cajal bodies in which it is found. It was first identified using human autoimmune serum.
== Function == Coilin protein is one of the main molecular components of Cajal bodies. Cajal bodies are non-membrane bound nuclear bodies of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. In addition to its structural role, coilin acts as glue to connect the CB to the nucleolus. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.
Excerpted from Wikipedia’s “COIL” article, available under the CC BY-SA 4.0 licence.
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