LITAF
Sign in to saveAlso known as PIG7, SIMPLE, TP53I7, lipopolysaccharide induced TNF factor
Lipopolysaccharide-induced tumor necrosis factor-alpha factor is a protein that in humans is encoded by the LITAF gene.
Gene data
LITAF- Name
- lipopolysaccharide induced TNF factor
- Type
- protein-coding
- Aliases
- PIG7, SIMPLE, TP53I7
Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 37974
- exact match
- identifiers.org/ncbigene/9516
- genomic end
- 11730237
- genomic start
- 11641853
- cytogenetic location
- 16p13.13
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Article
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Lipopolysaccharide-induced tumor necrosis factor-alpha factor is a protein that in humans is encoded by the LITAF gene.
It is associated with Charcot–Marie–Tooth disease 1C.