LITAF

Name

lipopolysaccharide induced TNF factor

Type

protein-coding

Position

11,546,224–11,640,269 (−)

Aliases

PIG7, SIMPLE, TP53I7

Ensembl

ENSG00000189067

RefSeq RNA

NM_001136472.2, NM_001136473.1, NM_004862.4, NR_024320.2, XM_006720982.4

RefSeq protein

NP_001129944.1, NP_001129945.1, NP_004853.2, XP_006721045.1, XP_006721046.1

Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014].

via MyGene.info

Gene · Ensembl

lipopolysaccharide induced TNF factor

Symbol

LITAF

Biotype

Protein coding

Organism

Homo sapiens

Location

16:11,546,224-11,640,269

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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