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GeneQ18037147· pop 5· linked from 50 articles

NCAPH

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Also known as BRRN1, CAP-H, non-SMC condensin I complex subunit H, MCPH23, CAPH

Condensin complex subunit 2 also known as chromosome-associated protein H (CAP-H) or non-SMC condensin I complex subunit H (NCAPH) is a protein that in humans is encoded by the NCAPH gene. CAP-H is a subunit of condensin I, a large protein complex involved in chromosome condensation. Abnormal expression of NCAPH may be linked to various types of carcinogenesis as a prognostic indicator.

Gene data

NCAPH
Name
non-SMC condensin I complex subunit H
Type
protein-coding
Position
96,335,728–96,377,091 (+)
Aliases
BRRN1, CAP-H, CAPH, MCPH23, NCAPH1
Ensembl
ENSG00000121152
RefSeq RNA
NM_001281710.2, NM_001281711.2, NM_001281712.2, NM_015341.5, XM_005263908.5
RefSeq protein
NP_001268639.1, NP_001268640.1, NP_001268641.1, NP_056156.2, XP_005263965.1

This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2013].

Gene Ontology

Pathways

Cell CycleCell CycleCondensation of Prometaphase ChromosomesCondensation of Prometaphase ChromosomesMitotic PrometaphaseMitotic PrometaphaseM PhaseM PhaseCell Cycle, MitoticCell Cycle, Mitotic

via MyGene.info

Gene · Ensembl

non-SMC condensin I complex subunit H

Symbol
NCAPH
Biotype
Protein coding
Organism
Homo sapiens
Location
2:96,335,728-96,377,091
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~3 min read

Encyclopedic overview

5 sections
Contents
  • Function
  • Structure and interactions
  • Clinical significance
  • References
  • Further reading

Condensin complex subunit 2 also known as chromosome-associated protein H (CAP-H) or non-SMC condensin I complex subunit H (NCAPH) is a protein that in humans is encoded by the NCAPH gene. CAP-H is a subunit of condensin I, a large protein complex involved in chromosome condensation. Abnormal expression of NCAPH may be linked to various types of carcinogenesis as a prognostic indicator.

== Function ==

Excerpted from Wikipedia’s “NCAPH” article, available under the CC BY-SA 4.0 licence.

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