Colony stimulating factor 1

Protein · UniProt

Macrophage colony-stimulating factor 1

Gene

CSF1

Organism

Homo sapiens (Human)

Length

554 aa

Molecular mass

60,179 Da

Evidence

1: Evidence at protein level

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the ac…

• PHASE2COMPLETED
  Colony-Stimulating Factors to Relieve Neutropenia in Patients With Recurrent Non-Hodgkin's LymphomaUniversity of Nebraska · NCT00004192
• PHASE2RECRUITING
  Cadonilimab Plus Anlotinib for R/M/P Cervical CancerZhongnan Hospital · NCT05817214
• PHASE3COMPLETED
  A Prospective, Randomized, Phase III Trial of FLAC (5-Fluorouracil, Leucovorin, Adriamycin, Cytoxan) Chemotherapy With GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) Versus PIXY 321 in Advanced Breast CancerNational Cancer Institute (NCI) · NCT00001338
• NACOMPLETED
  Treadmill Exercise and GM-CSF Study to Improving Functioning in Peripheral Artery Disease (PAD)Northwestern University · NCT01408901
• PHASE2ACTIVE_NOT_RECRUITING
  Vaccination of Patients With Ovarian Cancer With Dendritic Cell/Tumor Fusions With Granulocyte Macrophage Colony-stimulating Factor (GM-CSF) and ImiquimodBeth Israel Deaconess Medical Center · NCT00799110
• NACOMPLETED
  A Pilot Trial Evaluating an Alternating Schedule of Recombinant Human GM-CSF and Azidothymidine in Patients With HIV Infection and LeukopeniaSandoz · NCT00002007

via ClinicalTrials.gov