Structure via PubChem · Public domain (PubChem)
quizartinib
Sign in to saveAlso known as AC 010220, AC 220, AC220, AC010220, N-(5-(1,1-Dimethylethyl)isoxazol-3-yl)-N'-(4-(7-(2-(morpholin-4-yl)ethoxy)imidazo(2,1-b)benzothiazol-2-yl)phenyl)urea
Quizartinib, sold under the brand name Vanflyta, is an anti-cancer medication used for the treatment of acute myeloid leukemia.
Chemical data
- Formula
- C29H32N6O4S
- Molecular weight
- 560.7 g/mol
- IUPAC name
- 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[6-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea
- SMILES
- CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3
- InChIKey
- CVWXJKQAOSCOAB-UHFFFAOYSA-N
- XLogP
- 5.6
- Polar surface area
- 134 Ų
- H-bond donors
- 2
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2023
- Admin. routes
- oral
- Indications
- acute myeloid leukemia, neoplasm, liver disease, myelodysplastic syndrome
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 560.221
Show 6 more facts
- chemical formula
- C₂₉H₃₂N₆O₄S
- canonical SMILES
- CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3
- World Health Organisation international non-proprietary name
- quizartinib
- legal status (medicine)
- boxed warning
- subject has role
- protein kinase inhibitors
- medical condition treated
- acute myeloid leukemia
via Wikidata · CC0
~5 min read
Encyclopedic overview
11 sectionsContents
- Medical uses
- Adverse effects
- Mechanism of action
- History
- Clinical trials
- Society and culture
- Legal status
- Brand names
- References
- Further reading
- External links
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Quizartinib, sold under the brand name Vanflyta, is an anti-cancer medication used for the treatment of acute myeloid leukemia.
Excerpted from Wikipedia’s “quizartinib” article, available under the CC BY-SA 4.0 licence.