Structure via PubChem · Public domain (PubChem)
quizartinib
Sign in to saveAlso known as AC 010220, AC 220, AC220, AC010220, N-(5-(1,1-Dimethylethyl)isoxazol-3-yl)-N'-(4-(7-(2-(morpholin-4-yl)ethoxy)imidazo(2,1-b)benzothiazol-2-yl)phenyl)urea
Quizartinib, sold under the brand name Vanflyta, is an anti-cancer medication used for the treatment of acute myeloid leukemia.
In the Vinony graph
Within Vinony's link graph, quizartinib is referenced by 665 other articles, and connects out to KIT proto-oncogene, receptor tyrosine kinase, interferon gamma and peginterferon alfa-2a.
Vinony files it under 4-Morpholinyl compounds, Chemical articles with multiple CAS registry numbers and Chemical articles with multiple compound IDs.
Its subject is documented across 6 Wikipedia language editions.
Chemical data
- Formula
- C29H32N6O4S
- Molecular weight
- 560.7 g/mol
- IUPAC name
- 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[6-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea
- SMILES
- CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3
- InChIKey
- CVWXJKQAOSCOAB-UHFFFAOYSA-N
- XLogP
- 5.6
- Polar surface area
- 134 Ų
- H-bond donors
- 2
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2023
- Admin. routes
- oral
- Indications
- acute myeloid leukemia, neoplasm, liver disease, myelodysplastic syndrome
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 560.221
Show 6 more facts
- chemical formula
- C₂₉H₃₂N₆O₄S
- canonical SMILES
- CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3
- World Health Organisation international non-proprietary name
- quizartinib
- legal status (medicine)
- boxed warning
- subject has role
- protein kinase inhibitors
- medical condition treated
- acute myeloid leukemia
via Wikidata · CC0
~5 min read
Encyclopedic overview
11 sectionsContents
- Medical uses
- Adverse effects
- Mechanism of action
- History
- Clinical trials
- Society and culture
- Legal status
- Brand names
- References
- Further reading
- External links
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Quizartinib, sold under the brand name Vanflyta, is an anti-cancer medication used for the treatment of acute myeloid leukemia.
Excerpted from Wikipedia’s “quizartinib” article, available under the CC BY-SA 4.0 licence.