CD40 molecule
Sign in to saveAlso known as B cell-associated molecule, CD40, Bp50, tumor necrosis factor receptor superfamily member 5, CD40 Antigens, CD40L receptor, B cell surface antigen CD40, CD40 molecule, TNF receptor superfamily member 5
mammalian protein found in Homo sapiens
Protein · UniProt
Tumor necrosis factor receptor superfamily member 5
- Gene
- CD40
- Organism
- Homo sapiens (Human)
- Length
- 277 aa
- Molecular mass
- 30,619 Da
- Evidence
- 1: Evidence at protein level
Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity)
3D-structureAlternative splicingCell membraneDirect protein sequencingDisease variantDisulfide bondGlycoproteinImmunity
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Research
10,421 papers- The CD40/CD40 ligand dyad and its downstream effector molecule ISG54 in relating acute neuroinflammation with persistent, progressive demyelination.IUBMB life · 2024
- Small-molecule inhibitors of the CD40-CD40L costimulatory interaction are effective in pancreatic islet transplantation and prevention of type 1 diabetes models.Frontiers in immunology · 2024
- CD40 ligand: a neo-inflammatory molecule in vascular diseases.Immunobiology · 2012
- A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity.Cancer immunology research · 2019
- Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure.International journal of cardiology · 2019
via PubMed
Connections
T helper cell
Entity
interferon gamma
Entity
Q180686
Entity
macrophage
Entity
B-cell
Entity
carcinoma
Entity
Ensembl genome database project
Entity
peginterferon alfa-2a
Entity
germinal center
Entity
CD40LG
Gene
isotype switching
Entity
CD1
Entity
interferon type I
Entity
KIT proto-oncogene, receptor tyrosine kinase
Protein
Sialyl-Lewis X
Entity
tumor necrosis factor receptor
Entity
momelotinib
Entity
TFRC
Gene
TNF receptor superfamily member 1A
Protein
CSF1R
Gene