S100A1
Sign in to saveAlso known as S100, S100-alpha, S100A, S100 calcium-binding protein A1, S100 calcium binding protein A1
Protein S100-A1, also known as S100 calcium-binding protein A1 is a protein which in humans is encoded by the S100A1 gene. S100A1 is highly expressed in cardiac and skeletal muscle, and localizes to Z-discs and sarcoplasmic reticulum. S100A1 has shown promise as an effective candidate for gene therapy to treat post-myocardially infarcted cardiac tissue.
Gene data
S100A1- Name
- S100 calcium binding protein A1
- Type
- protein-coding
- Aliases
- S100, S100-alpha, S100A
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008].
via MyGene.info
Wikidata facts
- Image
- Protein S100A1 PDB 1k2h.png
Show 5 more facts
- HomoloGene ID
- 4566
- exact match
- identifiers.org/ncbigene/6271
- genomic end
- 153604513
- genomic start
- 153600402
- cytogenetic location
- 1q21.3
Sources (4)
via Wikidata · CC0
~9 min read
Article
13 sectionsContents
- Structure
- Function
- Clinical significance
- Expression changes in disease
- Cardiac disease
- Therapeutic potential
- Biomarker potential
- Drug interactions
- Research
- Interactions
- References
- Further reading
- External links
Protein S100-A1, also known as S100 calcium-binding protein A1 is a protein which in humans is encoded by the S100A1 gene. S100A1 is highly expressed in cardiac and skeletal muscle, and localizes to Z-discs and sarcoplasmic reticulum. S100A1 has shown promise as an effective candidate for gene therapy to treat post-myocardially infarcted cardiac tissue.
== Structure == S100A1 is a member of the S100 family of proteins expressed in cardiac muscle, skeletal muscle, and the brain, with the highest density at Z-lines and the sarcoplasmic reticulum. In its dimerized form, S100A1 contains four EF-hand calcium-binding motifs, and can exist as either a heterodimer or a homodimer. The homodimer is a high-affinity complex (nanomolar range or tighter) stabilized by hydrophobic packing within an X-type four-helix bundle formed by helices 1, 1, 4, and 4.