CREB3

Also known as LUMAN, LZIP, sLZIP, cAMP responsive element binding protein 3

Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene.

Gene data

CREB3

Name: cAMP responsive element binding protein 3
Type: protein-coding
Position: 35,732,296–35,738,886 (+)
Aliases: LUMAN, LZIP, sLZIP
Ensembl: ENSG00000107175
RefSeq RNA: NM_006368.5
RefSeq protein: NP_006359.3

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009].

Gene Ontology

Biological process

regulation of cell growth DNA-templated transcription regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II release from viral latency positive regulation of cell migration endoplasmic reticulum unfolded protein response

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific transcription coregulator binding DNA-binding transcription activator activity, RNA polymerase II-specific

Cellular component

Golgi membrane Golgi membrane chromatin nucleus nucleus nucleus nucleus nucleoplasm

Pathways

cGMP-PKG signaling pathway - Homo sapiens (human)cAMP signaling pathway - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)AMPK signaling pathway - Homo sapiens (human)Longevity regulating pathway - Homo sapiens (human)Adrenergic signaling in cardiomyocytes - Homo sapiens (human)TNF signaling pathway - Homo sapiens (human)Thermogenesis - Homo sapiens (human)Cholinergic synapse - Homo sapiens (human)Dopaminergic synapse - Homo sapiens (human)

via MyGene.info

Wikidata facts

Show 5 more facts

HomoloGene ID: 31375
exact match: identifiers.org/ncbigene/10488
genomic end: 35736999
genomic start: 35732598
cytogenetic location: 9p13.3

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Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene.

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.