CTSF

Also known as CATSF, CLN13, cathepsin F

protein-coding gene in the species Homo sapiens (Humans)

In the Vinony graph

Vinony's link graph records 87 inbound references to CTSF, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.

Vinony files it under Cathepsins, EC 3.4.22 and Genes on human chromosome 11.

Vinony links it to 8 Wikipedia language editions.

Gene data

CTSF

Name: cathepsin F
Type: protein-coding
Position: 66,563,462–66,568,879 (−)
Aliases: CATSF, CLN13
Ensembl: ENSG00000174080
RefSeq RNA: NM_003793.4, XM_011545328.3, XM_054370356.1
RefSeq protein: NP_003784.2, XP_011543630.1, XP_054226331.1

Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. [provided by RefSeq, Jul 2008].