CUL1

Also known as cullin 1

Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination.

Gene data

CUL1

Name: cullin 1
Type: protein-coding
Position: 148,697,914–148,801,110 (+)
Ensembl: ENSG00000055130
RefSeq RNA: NM_001370660.1, NM_001370661.1, NM_001370662.1, NM_001370663.1, NM_001370664.1
RefSeq protein: NP_001357589.1, NP_001357590.1, NP_001357591.1, NP_001357592.1, NP_001357593.1

Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Located in plasma membrane. Part of Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

Pathways

Cell cycle - Homo sapiens (human)Oocyte meiosis - Homo sapiens (human)Ubiquitin mediated proteolysis - Homo sapiens (human)Protein processing in endoplasmic reticulum - Homo sapiens (human)Wnt signaling pathway - Homo sapiens (human)Hedgehog signaling pathway - Homo sapiens (human)TGF-beta signaling pathway - Homo sapiens (human)Circadian rhythm - Homo sapiens (human)Shigellosis - Homo sapiens (human)Human immunodeficiency virus 1 infection - Homo sapiens (human)

via MyGene.info

Wikidata facts

Image: Protein CUL1 PDB 1ldj.png

Show 5 more facts

HomoloGene ID: 2663
exact match: identifiers.org/ncbigene/8454
genomic end: 148801110
genomic start: 148395006
cytogenetic location: 7q36.1

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Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination.

This is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, it serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.