DCTN3
Sign in to saveAlso known as DCTN-22, DCTN22, dynactin subunit 3
Dynactin subunit 3 is a protein that in humans is encoded by the DCTN3 gene.
In the Vinony graph
Within Vinony's link graph, DCTN3 is referenced by 2 other articles, and connects out to PubMed, human chromosome 9 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 9.
Its subject is documented across 5 Wikipedia language editions.
Gene data
DCTN3- Name
- dynactin subunit 3
- Type
- protein-coding
- Position
- 34,613,545–34,620,529 (−)
- Aliases
- DCTN-22, DCTN22
- Ensembl
- ENSG00000137100
- RefSeq RNA
- NM_001281425.2, NM_001281426.2, NM_001281427.2, NM_007234.5, NM_024348.4
- RefSeq protein
- NP_001268354.1, NP_001268355.1, NP_001268356.1, NP_009165.1, NP_077324.1
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
dynactin subunit 3
- Symbol
- DCTN3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:34,613,545-34,620,529
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 5233
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/11258
- genomic end
- 34620515
- genomic start
- 34613548
- chromosome
- human chromosome 9
- cytogenetic location
- 9p13.3
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Dynactin subunit 3 is a protein that in humans is encoded by the DCTN3 gene.
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants.
Excerpted from Wikipedia’s “DCTN3” article, available under the CC BY-SA 4.0 licence.