DCTN3
Sign in to saveAlso known as DCTN-22, DCTN22, dynactin subunit 3
Dynactin subunit 3 is a protein that in humans is encoded by the DCTN3 gene.
Gene data
DCTN3- Name
- dynactin subunit 3
- Type
- protein-coding
- Aliases
- DCTN-22, DCTN22
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 5233
- exact match
- identifiers.org/ncbigene/11258
- genomic end
- 34620515
- genomic start
- 34613548
- cytogenetic location
- 9p13.3
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- Further reading
Dynactin subunit 3 is a protein that in humans is encoded by the DCTN3 gene.
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants.