Structure via PubChem · Public domain (PubChem)
deferiprone
Sign in to saveAlso known as APO-66, CP20, Ferriprox®, 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone, 1,2-Dimethyl-3-hydroxypyrid-4-one, Deferiproni, PL-1, APO-066
Deferiprone, sold under the brand name Ferriprox among others, is a medication that chelates iron and is used to treat iron overload in thalassaemia major. It was first approved and indicated for use in treating thalassaemia major in 1994 and had been licensed for use in the European Union for many years while awaiting approval in Canada and in the United States. On 14 October 2011, it was approved for use in the US under the FDA's accelerated approval program.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 443270530
- Drug.image
- Deferiprone.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 120
- Drug.tradename
- Ferriprox
- Drug.MedlinePlus
- a612016
- Drug.DailyMedID
- Deferiprone
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- V03
- Drug.ATC_suffix
- AC02
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
- Drug.legal_UK_comment
- / P
- Drug.legal_US
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C7H9NO2
- Molecular weight
- 139.15 g/mol
- IUPAC name
- 3-hydroxy-1,2-dimethylpyridin-4-one
- SMILES
- CC1=C(C(=O)C=CN1C)O
- InChIKey
- TZXKOCQBRNJULO-UHFFFAOYSA-N
- XLogP
- 0.5
- Polar surface area
- 40.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
1,707 papers- Deferiprone in Alzheimer Disease: A Randomized Clinical Trial.JAMA neurology · 2025
- Deferiprone: New insight.Annals of the New York Academy of Sciences · 2005
- Deferiprone protects against photoreceptor degeneration by inhibiting parthanatos.Cell death & disease · 2025
- Deferiprone for the treatment of transfusional iron overload in thalassemia.Expert review of hematology · 2017
- Deferiprone: A Forty-Year-Old Multi-Targeting Drug with Possible Activity against COVID-19 and Diseases of Similar Symptomatology.International journal of molecular sciences · 2022
via PubMed
Wikidata facts
- Mass
- 139.063
Show 4 more facts
- chemical formula
- C₇H₉NO₂
- canonical SMILES
- CC1=C(C(=O)C=CN1C)O
- World Health Organisation international non-proprietary name
- deferiprone
- Commons category
- Deferiprone
via Wikidata · CC0
~3 min read
Article
4 sectionsContents
- Medical uses
- Controversy
- History
- References
Deferiprone, sold under the brand name Ferriprox among others, is a medication that chelates iron and is used to treat iron overload in thalassaemia major. It was first approved and indicated for use in treating thalassaemia major in 1994 and had been licensed for use in the European Union for many years while awaiting approval in Canada and in the United States. On 14 October 2011, it was approved for use in the US under the FDA's accelerated approval program.
The most common side effects include red-brown urine (showing that iron is being removed through the urine), nausea (feeling sick), abdominal pain (stomach ache) and vomiting. Less common but more serious side effects are agranulocytosis (very low levels of granulocytes, a type of white blood cell) and neutropenia (low levels of neutrophils, a type of white blood cell that fights infections).