Structure via PubChem · Public domain (PubChem)
delorazepam
Sign in to saveAlso known as Chlordesmethyldiazepam, Dadumir, CDDZ
Delorazepam, also known as chlordesmethyldiazepam and nordiclazepam, is a drug which is a benzodiazepine and a derivative of desmethyldiazepam. It is marketed in Italy, where it is available under the trade name EN. Delorazepam is also an active metabolite of the benzodiazepine drugs diclazepam and cloxazolam.
Chemical data
- Formula
- C15H10Cl2N2O
- Molecular weight
- 305.2 g/mol
- IUPAC name
- 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
- SMILES
- C1C(=O)NC2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3Cl
- InChIKey
- CHIFCDOIPRCHCF-UHFFFAOYSA-N
- XLogP
- 3.1
- Polar surface area
- 41.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
106 papers- Benzodiazepine Delorazepam Induces Locomotory Hyperactivity and Alterations in Pedal Mucus Texture in the Freshwater Gastropod Planorbarius corneus.International journal of molecular sciences · 2023
- Impact of Benzodiazepine Delorazepam on Growth and Behaviour of Artemia salina Nauplii.Biology · 2024
- Water contamination by delorazepam induces epigenetic defects in the embryos of the clawed frog Xenopus laevis.The Science of the total environment · 2023
- Environmental concentrations of a delorazepam-based drug impact on embryonic development of non-target Xenopus laevis.Aquatic toxicology (Amsterdam, Netherlands) · 2022
- Intravenous Augmentative Valproate Versus Delorazepam in Bipolar Patients With a Major Depressive Mixed Episode and Partial/Nonresponse to Oral Treatment: A Pilot Study.Journal of clinical psychopharmacology · 2021
via PubMed
Wikidata facts
- Subclass of
- alkaloid
- Mass
- 304.017018
- Has use
- medication
Show 6 more facts
- found in taxon
- Triticum aestivum
- MCN code
- 2933.91.21
- chemical formula
- C₁₅H₁₀Cl₂N₂O
- canonical SMILES
- C1C(=O)NC2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3Cl
- Commons category
- Delorazepam
- subject has role
- anticonvulsant agent
Sources (2)
via Wikidata · CC0
~8 min read
Encyclopedic overview
7 sectionsContents
- Indications
- Availability
- Pharmacology
- Side effects and contraindications
- Special cautions
- See also
- References
Delorazepam, also known as chlordesmethyldiazepam and nordiclazepam, is a drug which is a benzodiazepine and a derivative of desmethyldiazepam. It is marketed in Italy, where it is available under the trade name EN. Delorazepam is also an active metabolite of the benzodiazepine drugs diclazepam and cloxazolam.
Adverse effects may include hangover-type effects, drowsiness, behavioural impairments, and short-term memory impairments. Similar to other benzodiazepines delorazepam has anxiolytic, skeletal muscle relaxant, hypnotic, and anticonvulsant properties.
Excerpted from Wikipedia’s “delorazepam” article, available under the CC BY-SA 4.0 licence.