deoxyribonucleotide
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A deoxyribonucleotide is a nucleotide that contains deoxyribose. They are the monomeric units of the informational biopolymer, deoxyribonucleic acid (DNA). Each deoxyribonucleotide comprises three parts: a deoxyribose sugar (monosaccharide), a nitrogenous base, and one phosphoryl group. The nitrogenous bases are either purines or pyrimidines, heterocycles whose structures support the specific base-pairing interactions that allow nucleic acids to carry information. The base is always bonded to the 1'-carbon of the deoxyribose, an analog of ribose in which the hydroxyl group of the 2'-carbon is
Research
12,812 papers- Deoxyribonucleotide metabolism, mutagenesis and cancer.Nature reviews. Cancer · 2015
- Interactions between deoxyribonucleotide and DNA synthesis.Annual review of biochemistry · 1988
- Deoxyribonucleotide synthesis in anaerobic microorganisms: the class III ribonucleotide reductase.Progress in nucleic acid research and molecular biology · 2002
- Ribonucleotide incorporation into mitochondrial DNA drives inflammation.Nature · 2025
- Ribonucleotide reductase and deoxyribonucleotide pools.Basic life sciences · 1985
via PubMed
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Encyclopedic overview
3 sectionsContents
- Deoxyribonucleoside
- References
- External links
A deoxyribonucleotide is a nucleotide that contains deoxyribose. They are the monomeric units of the informational biopolymer, deoxyribonucleic acid (DNA). Each deoxyribonucleotide comprises three parts: a deoxyribose sugar (monosaccharide), a nitrogenous base, and one phosphoryl group. The nitrogenous bases are either purines or pyrimidines, heterocycles whose structures support the specific base-pairing interactions that allow nucleic acids to carry information. The base is always bonded to the 1'-carbon of the deoxyribose, an analog of ribose in which the hydroxyl group of the 2'-carbon is replaced with a hydrogen atom. The third component, the phosphoryl group, attaches to the deoxyribose monomer via the hydroxyl group on the 5'-carbon of the sugar.
When deoxyribonucleotides polymerize to form DNA, the phosphate group from one nucleotide will bond to the 3' carbon on another nucleotide, forming a phosphodiester bond via dehydration synthesis. New nucleotides are always added to the 3' carbon of the last nucleotide, so synthesis always proceeds from 5' to 3'.
Excerpted from Wikipedia’s “deoxyribonucleotide” article, available under the CC BY-SA 4.0 licence.