desmosome
Sign in to saveAlso known as GO:0030057, spot desmosome, macula adherens, desmosomes
A desmosome (; "binding body"), also known as a macula adherens (plural: maculae adherentes) (Latin for adhering spot), is a cell structure specialized for cell-to-cell adhesion. A type of junctional complex, they are localized spot-like adhesions randomly arranged on the lateral sides of plasma membranes. Desmosomes are one of the stronger cell-to-cell adhesion types and are found in tissue that experience intense mechanical stress, such as cardiac muscle tissue, bladder tissue, gastrointestinal mucosa, and epithelia.
Key facts
- Anatomy.Name
- Desmosome
- Anatomy.Latin
- DesmosomaMacula adhaerens
- Anatomy.Image
- Desmosome cell junction en.svg
- Anatomy.Caption
- A desmosome.
- Anatomy.Image2
- Desmosome_-_2.png
- Anatomy.Caption2
- The extracellular core region containing desmocollin and desmoglein, and the plaque contain desmoplakin, which attaches to keratin intermediate filaments. Desmosome is a intercellular junction in animal cell.
via Wikipedia infobox
Research
8,828 papers- The desmosome comes into focus.The Journal of cell biology · 2024
- The desmosome.Cold Spring Harbor perspectives in biology · 2009
- Desmosome assembly and dynamics.Trends in cell biology · 2013
- The desmosome as a model for lipid raft driven membrane domain organization.Biochimica et biophysica acta. Biomembranes · 2020
- The desmosome and pemphigus.Histochemistry and cell biology · 2008
via PubMed
~6 min read
Encyclopedic overview
8 sectionsContents
- Structure
- Clinical significance
- Arrhythmogenic cardiomyopathy
- Blisters
- History
- See also
- References
- External links
A desmosome (; "binding body"), also known as a macula adherens (plural: maculae adherentes) (Latin for adhering spot), is a cell structure specialized for cell-to-cell adhesion. A type of junctional complex, they are localized spot-like adhesions randomly arranged on the lateral sides of plasma membranes. Desmosomes are one of the stronger cell-to-cell adhesion types and are found in tissue that experience intense mechanical stress, such as cardiac muscle tissue, bladder tissue, gastrointestinal mucosa, and epithelia.
==Structure== Desmosomes are composed of desmosome-intermediate filament complexes (DIFCs), a network of cadherin proteins, linker proteins and intermediate filaments. The DIFCs can be broken into three regions: the extracellular core region ("desmoglea"), the outer dense plaque (ODP), and the inner dense plaque (IDP).
Excerpted from Wikipedia’s “desmosome” article, available under the CC BY-SA 4.0 licence.