Structure via PubChem · Public domain (PubChem)
دزومورفین
Sign in to saveAlso known as dihydrodesoxymorphine, krokodil, 4,5-epoxy-3-hydroxy-n-methylmorphinan, 6-deoxy-7,8-dihydromorphine, deoxydihydromorphine D, dihydrodeoxymorphine, dihydrodesoxymorphine D, krok
Desomorphine (or in some formulations known as Krokodil) is a semi-synthetic opioid commercialized by Roche, with powerful, fast-acting effects, such as sedation and analgesia. It was first discovered and patented in Germany by a German team working for Knoll in 1920 but was not generally recognized. It was later synthesized in 1932 by American chemist Lyndon Frederick Small. Small also successfully patented it in 1934 in the United States. Desomorphine was used in Germany, Austria, and Switzerland under the brand name Permonid and was described as having a fast onset and a short duration of a
Chemical data
- Formula
- C17H21NO2
- Molecular weight
- 271.35 g/mol
- IUPAC name
- (4R,4aR,7aS,12bS)-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-ol
- SMILES
- CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3CCC4
- InChIKey
- LNNWVNGFPYWNQE-GMIGKAJZSA-N
- XLogP
- 2.8
- Polar surface area
- 32.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
60 papers- Desomorphine goes "crocodile".Journal of addictive diseases · 2012
- DARK Classics in Chemical Neuroscience: Heroin and Desomorphine.ACS chemical neuroscience · 2020
- Desomorphine (Krokodil): An overview of its chemistry, pharmacology, metabolism, toxicology and analysis.Drug and alcohol dependence · 2017
- Effects of krokodil (desomorphine) use on oral health - a systematic review.British dental journal · 2019
- Necrotic Lesions Associated with Desomorphine ("Krokodil") Drug Abuse: a Systematic Review.Journal of oral & maxillofacial research · 2025
via PubMed
Wikidata facts
Show 6 more facts
- Commons category
- Desomorphine
- melting point
- 189
- chemical formula
- C₁₇H₂₁NO₂
- canonical SMILES
- CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3CCC4
- isomeric SMILES
- CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3CCC4
- subject has role
- opioid
via Wikidata · CC0