Structure via PubChem · Public domain (PubChem)
デキストロチロキシン
Sign in to saveAlso known as Choloxin®, D-T4, D-thyroxine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine, DT4, Dextrothyroxine, O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine
Dextrothyroxine (trade name Choloxin) is a dextrorotary isomer of thyroxine. It saw research as a cholesterol-lowering drug but was pulled due to cardiac side-effects. It increases hepatic lipase which in turn improves utilization of triglycerides and decreases levels of lipoprotein(a) in blood serum.
Chemical data
- Formula
- C15H11I4NO4
- Molecular weight
- 776.87 g/mol
- IUPAC name
- (2R)-2-azaniumyl-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1967
- Admin. routes
- oral
- Indications
- cardiovascular disease, Down syndrome
via ChEMBL · EBI
Research
309 papers- THE EFFECTS OF DEXTROTHYROXINE IN DIABETES.California medicine · 1964
- Dextrothyroxine.New York state journal of medicine · 1972
- Comparative effectiveness of dextrothyroxine and levothyroxine in correcting hypothyroidism and lowering blood lipid levels in hypothyroid patients.The Journal of clinical endocrinology and metabolism · 1979
- Dextrothyroxine for lowering cholesterol.The Medical letter on drugs and therapeutics · 1976
- Adverse effects of hypolipidaemic drugs.Medical toxicology · 1987
via PubMed
Wikidata facts
- Subclass of
- thyroxine
- Mass
- 776.6867
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₅H₁₁I₄NO₄
- medical condition treated
- coronary artery disease
- canonical SMILES
- C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)O)N
- isomeric SMILES
- C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@H](C(=O)O)N
- defined daily dose
- 4
Sources (3)
via Wikidata · CC0
Article · 日本語
デキストロチロキシン（Dextrothyroxine）は、チロキシンのD-異性体（右旋性）である。コレステロールを下げる薬として研究されたが、心臓の副作用の為に中止された。肝リパーゼを増加させ、トリグリセリドの利用率を高め、血清中のの濃度を低下させる。左旋性のL-チロキシンは、内因性の甲状腺ホルモンであると同時に、甲状腺ホルモン補充療法に用いられる医薬品である。
Abstract from DBpedia / Wikipedia · CC BY-SA
Available in 11 languages
via Wikidata sitelinks · CC0