Structure via PubChem · Public domain (PubChem)
diethylcarbamazine
Sign in to saveAlso known as Carbamazine, Camin, N,N-Diethyl-4-methyl-1-piperazinecarboxamide, Diethylcarbamazin, Diéthylcarbamazine, Diethylcarbamazinum, Dietilcarbamazina
Diethylcarbamazine is a medication used in the treatment of filariasis including lymphatic filariasis, tropical pulmonary eosinophilia, and loiasis. It may also be used for prevention of loiasis in those at high risk. While it has been used for onchocerciasis (river blindness), ivermectin is preferred. It is taken by mouth.
Key facts
- Drug.ChEMBL
- 684
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 412749783
- Drug.image
- Diethylcarbamazine.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Diethylcarbamazine ball-and-stick model from xtal 2010.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 250px
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- P02
- Drug.ATC_suffix
- CB02
- Drug.legal_status
- Rx Only
- Drug.CAS_number
- 90-89-1
- Drug.PubChem
- 3052
- Drug.DrugBank
- DB00711
- Drug.ChemSpiderID
- 2944
- Drug.UNII
- V867Q8X3ZD
- Drug.KEGG
- D07825
via Wikipedia infobox
Chemical data
- Formula
- C10H21N3O
- Molecular weight
- 199.29 g/mol
- IUPAC name
- N,N-diethyl-4-methylpiperazine-1-carboxamide
- SMILES
- CCN(CC)C(=O)N1CCN(CC1)C
- InChIKey
- RCKMWOKWVGPNJF-UHFFFAOYSA-N
- XLogP
- 0.3
- Polar surface area
- 26.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1950
- Admin. routes
- oral
- Indications
- infection, filarial elephantiasis, loiasis, Helminthiasis
via ChEMBL · EBI
Research
2,642 papers- [Diethylcarbamazine in the treatment of Bancroft's filariasis].Revista da Sociedade Brasileira de Medicina Tropical · 1997
- Diethylcarbamazine in the treatment of patients with onchocerciasis.British journal of clinical pharmacology · 1992
- Diethylcarbamazine activates TRP channels including TRP-2 in filaria, Brugia malayi.Communications biology · 2020
- Diethylcarbamazine and new compounds for the treatment of filariasis.Advances in pharmacology and chemotherapy · 1979
- Diethylcarbamazine-related immunity.The Journal of infectious diseases · 1995
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 199.168
Show 5 more facts
- defined daily dose
- 0.4
- chemical formula
- C₁₀H₂₁N₃O
- canonical SMILES
- CCN(CC)C(=O)N1CCN(CC1)C
- subject has role
- essential medicine
- Commons category
- Diethylcarbamazine
via Wikidata · CC0
~2 min read
Encyclopedic overview
8 sectionsContents
- Medical uses
- Contraindications
- Mechanism
- Society and culture
- Brand names
- Veterinary uses
- References
- External links
Diethylcarbamazine is a medication used in the treatment of filariasis including lymphatic filariasis, tropical pulmonary eosinophilia, and loiasis. It may also be used for prevention of loiasis in those at high risk. While it has been used for onchocerciasis (river blindness), ivermectin is preferred. It is taken by mouth.
Common side effects include itching, facial swelling, headaches, and feeling tired. Other side effects include vision loss and dizziness. It is a recommended treatment in pregnancy and appears to be safe for the baby. The World Health Organization; however, recommends waiting until after pregnancy for treatment when feasible. It is made from 4-methyl-piperazine.
Excerpted from Wikipedia’s “diethylcarbamazine” article, available under the CC BY-SA 4.0 licence.