File:Ivermectin_skeletal.svg · Wikimedia Commons · See Wikimedia Commons
ivermectin
Sign in to saveIvermectin is an antiparasitic medication. After its discovery in 1975, its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. Approved for human use in 1987, it is used to treat infestations including head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis and lymphatic filariasis. It works through many mechanisms to kill the targeted parasites, and can be taken by mouth, or applied to the skin for external infestations. It belongs to the avermectin family of medications.
OverviewAI-generated
Ivermectin is a chemical compound with the formula C₉₅H₁₄₆O₂₈. Its mass is 1736.2, and it has a defined daily dose of 12. The molecule possesses a topological polar surface area of 340, with 6 hydrogen bond donors and 28 hydrogen bond acceptors. It carries a charge of 0.
The compound is identified by the InChIKey SPBDXSGPUHCETR-JFUDTMANSA-N and the NCI Thesaurus ID C61796. It is associated with a PubChem CID of 9812710. A Commons category exists for ivermectin. The subject is referenced by 1,644 other encyclopedia articles and has a PubMed count of 11981.
Synthesized by Vinony from 15 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Chemical data
- Formula
- C95H146O28
- Molecular weight
- 1736.2 g/mol
- IUPAC name
- (1R,4S,5'S,6R,6'R,8R,10E,12S,13S,14E,16E,20R,21R,24S)-6'-[(2S)-butan-2-yl]-21,24-dihydroxy-12-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one;(1R,4S,5'S,6R,6'R,8R,10E,12S,13S,14E,16E,20R,21R,24S)-21,24-dihydroxy-12-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethyl-6'-propan-2-ylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
- SMILES
- CC[C@H](C)[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)C.C[C@H]1CC[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)O[C@@H]1C(C)C
- InChIKey
- SPBDXSGPUHCETR-JFUDTMANSA-N
- Polar surface area
- 340 Ų
- H-bond donors
- 6
- H-bond acceptors
- 28
- Formal charge
- 0
via PubChem
Research
11,981 papers- Ivermectin, a potential anticancer drug derived from an antiparasitic drug.Pharmacological research · 2021
- Ivermectin: a mini-review.Clinical toxicology (Philadelphia, Pa.) · 2022
- Ivermectin in Cancer Treatment: Should Healthcare Providers Caution or Explore Its Therapeutic Potential?Current oncology reports · 2025
- Ivermectin for preventing and treating COVID-19.The Cochrane database of systematic reviews · 2022
- Ivermectin and non-parasitic disorders: An update.Current opinion in pharmacology · 2025
via PubMed
~21 min read
Encyclopedic overview
23 sectionsContents
- Medical uses
- Worm infections
- Mites and insects
- Contraindications
- Adverse effects
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Chemistry
- History
- Society and culture
- COVID-19 misinformation
- Economics
- Brand names
- Research
- Parasitic disease
- Tropical diseases
- NAFLD
- COVID-19
- Veterinary use
- Notes
- References
- External links
Ivermectin is an antiparasitic medication. After its discovery in 1975, its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. Approved for human use in 1987, it is used to treat infestations including head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis and lymphatic filariasis. It works through many mechanisms to kill the targeted parasites, and can be taken by mouth, or applied to the skin for external infestations. It belongs to the avermectin family of medications.
William Campbell and Satoshi Ōmura were awarded the 2015 Nobel Prize in Physiology or Medicine for its discovery and applications. It is on the World Health Organization's List of Essential Medicines. and is approved by the US Food and Drug Administration (FDA) as an antiparasitic agent. In 2023, it was the 295th most commonly prescribed medication in the United States, with more than 400,000 prescriptions. It is available as a generic medicine. Ivermectin is available in a fixed-dose combination with albendazole.
Excerpted from Wikipedia’s “ivermectin” article, available under the CC BY-SA 4.0 licence.