CYP2A6

Also known as CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB, cytochrome P450 family 2 subfamily A member 6

Cytochrome P450 2A6 (abbreviated CYP2A6) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. CYP2A6 is the primary enzyme responsible for the oxidation of nicotine and cotinine. It is also involved in the metabolism of several pharmaceuticals, carcinogens, and a number of coumarin-type alkaloids. CYP2A6 is the only enzyme in the human body that appreciably catalyzes the 7-hydroxylation of coumarin, such that the formation of the product of this reaction, 7-hydroxycoumarin, is used as a probe for CYP2A6 activity.

Gene data

CYP2A6

Name: cytochrome P450 family 2 subfamily A member 6
Type: protein-coding
Position: 40,843,533–40,850,450 (−)
Aliases: CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB
Ensembl: ENSG00000255974
RefSeq RNA: NM_000762.6
RefSeq protein: NP_000753.3

This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

xenobiotic metabolic process xenobiotic metabolic process xenobiotic metabolic process steroid metabolic process coumarin metabolic process coumarin metabolic process coumarin metabolic process epoxygenase P450 pathway

Molecular function

monooxygenase activity iron ion binding protein binding coumarin 7-hydroxylase activity coumarin 7-hydroxylase activity arachidonate epoxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

Cellular component

cytoplasm endoplasmic reticulum membrane endoplasmic reticulum membrane cytoplasmic microtubule intracellular membrane-bounded organelle

Pathways

Caffeine metabolism - Homo sapiens (human)Retinol metabolism - Homo sapiens (human)Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)Drug metabolism - cytochrome P450 - Homo sapiens (human)Drug metabolism - other enzymes - Homo sapiens (human)Chemical carcinogenesis - Homo sapiens (human)Lipid and atherosclerosis - Homo sapiens (human)Metabolism Biological oxidations Cytochrome P450 - arranged by substrate type

via MyGene.info

Wikidata facts

Image: Protein CYP2A6 PDB 1z10.png

Show 5 more facts

HomoloGene ID: 85917
exact match: identifiers.org/ncbigene/1548
genomic start: 40843541
genomic end: 41388657
cytogenetic location: 19q13.2

Sources (5)

via Wikidata · CC0

~3 min read

Article

9 sections

Contents

Interactive pathway map
Distribution
Variability
Induction
CYP2A6 Ligands
See also
References
Further reading
External links

The CYP2A6 gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.