EntityQ415734· pop 10· linked from 485 articles

aminopterin

Aminopterin (or 4-aminopteroic acid), the 4–amino derivative of folic acid, is an antineoplastic drug with immunosuppressive properties often used in chemotherapy. Aminopterin is a synthetic derivative of pterin. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effectively blocks tetrahydrofolate synthesis. This results in the depletion of nucleotide precursors and inhibition of DNA, RNA, and protein synthesis.

Research

45,124 papers

[Aminopterin].Nordisk medicin · 1955
[Fetal aminopterin syndrome].Ryoikibetsu shokogun shirizu · 2001
[Fetal aminopterin syndrome].Ryoikibetsu shokogun shirizu · 2000
Aminopterin for psoriasis.A.M.A. archives of dermatology · 1955
Aminopterin in leukemia.Archives of pediatrics · 1950

via PubMed

Article

4 sections

Contents

Uses
Implication in 2007 Menu Foods recall
Exposure and treatment
References

{{chembox | Watchedfields = changed | verifiedrevid = 413853192 | ImageFile_Ref = | ImageFile = Aminopterin structural formula V2.svg | ImageClass = skin-invert-image | ImageSize = 300px | ImageFile1 = Aminopterin ball-and-stick.png | ImageClass1 = bg-transparent | ImageSize1 = 300px | IUPACName = N-(4-{[(2,4-Diaminopteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid | SystematicName = (2S)-2-(4-{[(2,4-Diaminopteridin-6-yl)methyl]amino}benzamido)pentanedioic acid | OtherNames = 4-Aminofolic acid4-Aminopteroylglutamic acidAminopterin sodiumAminopteroylglutamic acid | Section1 = | Section2 = }} Aminopterin (or 4-aminopteroic acid), the 4–amino derivative of folic acid, is an antineoplastic drug with immunosuppressive properties often used in chemotherapy. Aminopterin is a synthetic derivative of pterin. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effectively blocks tetrahydrofolate synthesis. This results in the depletion of nucleotide precursors and inhibition of DNA, RNA, and protein synthesis.

It is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002), and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities.