dishevelled
Sign in to saveAlso known as Dishevelled protein domain family, IPR003351, dishevelled proteins, dishevelled protein
Dishevelled (Dsh) is a family of proteins involved in canonical and non-canonical Wnt signalling pathways. Dsh (Dvl in mammals) is a cytoplasmic phosphoprotein that acts directly downstream of frizzled receptors. It takes its name from its initial discovery in flies, where a mutation in the dishevelled gene was observed to cause improper orientation of body and wing hairs. There are vertebrate homologs in zebrafish, Xenopus (Xdsh), mice (Dvl1, -2, -3) and humans (DVL-1, -2, -3). Dsh relays complex Wnt signals in tissues and cells, in normal and abnormal contexts. It is thought to interact with
Research
1,960 papers- Dishevelled: An emerging therapeutic oncogene in human cancers.Pathology, research and practice · 2023
- Decoding Dishevelled-Mediated Wnt Signaling in Vertebrate Early Development.Frontiers in cell and developmental biology · 2020
- Nuclear Dishevelled: An enigmatic role in governing cell fate and Wnt signaling.Biochimica et biophysica acta. Molecular cell research · 2022
- Dishevelled: A masterful conductor of complex Wnt signals.Cellular signalling · 2018
- Structural and Functional Insights into Dishevelled-Mediated Wnt Signaling.Cells · 2024
via PubMed
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Encyclopedic overview
15 sectionsContents
- Members
- Function
- Wnt canonical pathway
- Wnt non-canonical pathways
- Planar cell polarity pathway
- Wnt-calcium pathway
- Structure
- DIX domain (''Di''shevelled-A''x''in)
- PDZ domain
- DEP domain (''D''ishevelled-''E''GL-10-''P''leckstrin)
- NES and NLS regions
- Post-translational modifications
- Alignment of dishevelled-specific domain
- References
- External links
Dishevelled (Dsh) is a family of proteins involved in canonical and non-canonical Wnt signalling pathways. Dsh (Dvl in mammals) is a cytoplasmic phosphoprotein that acts directly downstream of frizzled receptors. It takes its name from its initial discovery in flies, where a mutation in the dishevelled gene was observed to cause improper orientation of body and wing hairs. There are vertebrate homologs in zebrafish, Xenopus (Xdsh), mice (Dvl1, -2, -3) and humans (DVL-1, -2, -3). Dsh relays complex Wnt signals in tissues and cells, in normal and abnormal contexts. It is thought to interact with the SPATS1 protein when regulating the Wnt Signalling pathway.
Dishevelled plays important roles in both the embryo and the adult, ranging from cellular differentiation and cell polarity to social behavior.
Excerpted from Wikipedia’s “dishevelled” article, available under the CC BY-SA 4.0 licence.