DVL2
Sign in to saveAlso known as dishevelled segment polarity protein 2
Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene.
Gene data
DVL2- Name
- dishevelled segment polarity protein 2
- Type
- protein-coding
- Position
- 7,225,342–7,234,524 (−)
- Ensembl
- ENSG00000004975
- RefSeq RNA
- NM_004422.3, XM_005256502.3, XM_047435518.1, XM_047435519.1, XM_047435520.1
- RefSeq protein
- NP_004413.1, XP_005256559.1, XP_047291474.1, XP_047291475.1, XP_047291476.1
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
- Image
- Protein DVL2 PDB 1l6o.png
Show 5 more facts
- HomoloGene ID
- 20927
- exact match
- identifiers.org/ncbigene/1856
- genomic end
- 7234517
- genomic start
- 7225342
- cytogenetic location
- 17p13.1
Sources (3)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Interactions
- See also
- References
- Further reading
Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene.
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.