WNT1
Sign in to saveAlso known as BMND16, INT1, OI15, Wnt family member 1
WNT1 is a gene that encodes the WNT1 protein. It is a proto-oncogene involved in regulating embryonic development and is highly conserved among animals. WNT1 was previously known as INT1 in mammals and Wg (or "wingless") in Drosophila. In 1987, it was discovered that they were the same gene (i.e. they were homologous), and the gene was subsequently renamed WNT1 as a portmanteau of wingless and int-1.
Gene data
WNT1- Name
- Wnt family member 1
- Type
- protein-coding
- Position
- 48,978,322–48,982,620 (+)
- Aliases
- BMND16, INT1, OI15
- Ensembl
- ENSG00000125084
- RefSeq RNA
- NM_005430.4
- RefSeq protein
- NP_005421.1
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
Wnt family member 1
- Symbol
- WNT1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:48,978,322-48,982,620
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- cytogenetic location
- 12q13.12
- HomoloGene ID
- 3963
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/7471
- genomic end
- 48982620
- genomic start
- 48978322
- chromosome
- human chromosome 12
- expressed in
- Brodmann area 9
Sources (4)
via Wikidata · CC0
~6 min read
Encyclopedic overview
8 sectionsContents
- Gene
- Structure
- Function
- Clinical significance
- History
- See also
- References
- Further reading
WNT1 is a gene that encodes the WNT1 protein. It is a proto-oncogene involved in regulating embryonic development and is highly conserved among animals. WNT1 was previously known as INT1 in mammals and Wg (or "wingless") in Drosophila. In 1987, it was discovered that they were the same gene (i.e. they were homologous), and the gene was subsequently renamed WNT1 as a portmanteau of wingless and int-1.
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum.
Excerpted from Wikipedia’s “WNT1” article, available under the CC BY-SA 4.0 licence.