DKK3
Sign in to saveAlso known as REIC, RIG, dickkopf WNT signaling pathway inhibitor 3, CRRL
Dickkopf-related protein 3 is a protein in the Dickkopf family that in humans is encoded by the DKK3 gene.
In the Vinony graph
Vinony's link graph records 3 inbound references to DKK3, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 11.
Vinony links it to 6 Wikipedia language editions.
Gene data
DKK3- Name
- dickkopf Wnt signaling pathway inhibitor 3
- Type
- protein-coding
- Position
- 11,956,207–12,009,948 (−)
- Aliases
- CRRL, REIC, RIG
- Ensembl
- ENSG00000050165
- RefSeq RNA
- NM_001018057.2, NM_001330220.3, NM_013253.5, NM_015881.6, XM_006718178.3
- RefSeq protein
- NP_001018067.1, NP_001317149.1, NP_037385.2, NP_056965.3, XP_006718241.1
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
dickkopf Wnt signaling pathway inhibitor 3
- Symbol
- DKK3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:11,956,207-12,009,948
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 8303
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/27122
- genomic end
- 12031316
- genomic start
- 11956207
- chromosome
- human chromosome 11
- cytogenetic location
- 11p15.3
- expressed in
- vena cava
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Dickkopf-related protein 3 is a protein in the Dickkopf family that in humans is encoded by the DKK3 gene.
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.
Excerpted from Wikipedia’s “DKK3” article, available under the CC BY-SA 4.0 licence.