Structure via PubChem · Public domain (PubChem)
sultopride
Sign in to saveSultopride (trade names Barnetil, Barnotil, Topral) is an atypical antipsychotic of the benzamide chemical class used in Europe, Japan, and Hong Kong for the treatment of schizophrenia. It was launched by Sanofi-Aventis in 1976. Sultopride acts as a selective D2 and D3 receptor antagonist. It has also been shown to have clinically relevant affinity for the GHB receptor as well, a property it shares in common with amisulpride and sulpiride.
Chemical data
- Formula
- C17H26N2O4S
- Molecular weight
- 354.5 g/mol
- IUPAC name
- N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide
- SMILES
- CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)CC)OC
- InChIKey
- UNRHXEPDKXPRTM-UHFFFAOYSA-N
- XLogP
- 1.6
- Polar surface area
- 84.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- psychosis
via ChEMBL · EBI
Research
1,689 papers- Amisulpride.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2020
- Biotransformation of sultopride in man and several animal species.Xenobiotica; the fate of foreign compounds in biological systems · 1985
- Amisulpride augmentation therapy improves cognitive performance and psychopathology in clozapine-resistant treatment-refractory schizophrenia: a 12-week randomized, double-blind, placebo-controlled trial.Military Medical Research · 2022
- The antipsychotic sultopride is overdosed--a PET study of drug-induced receptor occupancy in comparison with sulpiride.The international journal of neuropsychopharmacology · 2006
- Focus on amisulpride.Current medical research and opinion · 2002
via PubMed
Wikidata facts
- Subclass of
- heterocyclic compound
- Has part
- carbon
- Mass
- 354.161
Show 5 more facts
- chemical formula
- C₁₇H₂₆N₂O₄S
- canonical SMILES
- CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)CC)OC
- Commons category
- Sultopride
- subject has role
- dopamine antagonist
- MCN code
- 2933.99.43
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Pharmacology
- References
Sultopride (trade names Barnetil, Barnotil, Topral) is an atypical antipsychotic of the benzamide chemical class used in Europe, Japan, and Hong Kong for the treatment of schizophrenia. It was launched by Sanofi-Aventis in 1976. Sultopride acts as a selective D2 and D3 receptor antagonist. It has also been shown to have clinically relevant affinity for the GHB receptor as well, a property it shares in common with amisulpride and sulpiride.
== Pharmacology == {| class="wikitable sortable" |+Sultopride !Site !Ki !Species !Ref |- |D2 |1.6 |Human | |- |D3 |3.8 |Human | |}
Excerpted from Wikipedia’s “sultopride” article, available under the CC BY-SA 4.0 licence.