DRD1
Sign in to saveAlso known as dopamine receptor D1, DADR, DRD1A
protein-coding gene in the species Homo sapiens
Gene data
DRD1- Name
- dopamine receptor D1
- Type
- protein-coding
- Position
- 175,440,027–175,444,794 (−)
- Aliases
- D1R, DADR, DRD1A
- Ensembl
- ENSG00000184845
- RefSeq RNA
- NM_000794.5
- RefSeq protein
- NP_000785.1
This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
synaptic transmission, dopaminergicG protein-coupled receptor signaling pathwayG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengeradenylate cyclase-activating G protein-coupled receptor signaling pathwayadenylate cyclase-activating G protein-coupled receptor signaling pathwayadenylate cyclase-activating dopamine receptor signaling pathwayadenylate cyclase-activating dopamine receptor signaling pathwayadenylate cyclase-activating dopamine receptor signaling pathway
Molecular function
dopamine neurotransmitter receptor activity, coupled via Gsdopamine neurotransmitter receptor activity, coupled via Gsdopamine neurotransmitter receptor activity, coupled via Gsdopamine neurotransmitter receptor activity, coupled via GsG-protein alpha-subunit bindingG protein-coupled receptor activityG protein-coupled receptor activitydopamine neurotransmitter receptor activity
Pathways
Calcium signaling pathway - Homo sapiens (human)cAMP signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Gap junction - Homo sapiens (human)Dopaminergic synapse - Homo sapiens (human)Parkinson disease - Homo sapiens (human)Cocaine addiction - Homo sapiens (human)Amphetamine addiction - Homo sapiens (human)Morphine addiction - Homo sapiens (human)Alcoholism - Homo sapiens (human)
via MyGene.info
Gene · Ensembl
dopamine receptor D1
- Symbol
- DRD1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:175,440,027-175,444,794
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 30992
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1812
- cytogenetic location
- 5q35.2
- genomic end
- 175444182
- genomic start
- 175440036
- chromosome
- human chromosome 5
- Commons category
- DRD1
- expressed in
- Brodmann area 46
via Wikidata · CC0