Structure via PubChem · Public domain (PubChem)
ketanserin
Sign in to saveKetanserin, sold under the brand name Sufrexal, is an antihypertensive agent which is used to treat arterial hypertension and vasospastic disorders. It is also used in scientific research as an antiserotonergic agent in the study of the serotonin system; specifically, the 5-HT2 receptor family. The drug is taken orally.
Chemical data
- Formula
- C22H22FN3O3
- Molecular weight
- 395.4 g/mol
- IUPAC name
- 3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione
- SMILES
- C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=CC=CC=C4NC3=O
- InChIKey
- FPCCSQOGAWCVBH-UHFFFAOYSA-N
- XLogP
- 2.6
- Polar surface area
- 69.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- diabetic foot, Acute kidney injury, hypertension
via ChEMBL · EBI
Research
5,342 papers- Ketanserin: a novel cardiovascular drug.Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis · 1990
- Clinical pharmacokinetics of ketanserin.Clinical pharmacokinetics · 1991
- Ageing, serotonin and ketanserin.Drugs · 1988
- Ketanserin for Raynaud's phenomenon in progressive systemic sclerosis.The Cochrane database of systematic reviews · 2000
- Ketanserin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in hypertension and peripheral vascular disease.Drugs · 1990
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 395.16452
Show 5 more facts
- chemical formula
- C₂₂H₂₂FN₃O₃
- canonical SMILES
- C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=CC=CC=C4NC3=O
- subject has role
- platelet aggregation inhibitors
- Commons category
- Ketanserin
- defined daily dose
- 40
Sources (6)
via Wikidata · CC0
~9 min read
Encyclopedic overview
15 sectionsContents
- Uses
- Medical uses
- Research uses
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- Synthesis
- Analogues
- History
- Society and culture
- Names
- See also
- References
- External links
{{Drugbox | Verifiedfields = verified | Watchedfields = verified | verifiedrevid = 420466712 | image = Ketanserin.svg | image_class = skin-invert-image | width = 250px | image2 = Ketanserin_3D.png | image_class2 = bg-transparent | width2 = 235px
| tradename = Sufrexal, Serefrex | Drugs.com = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | routes_of_administration = Oral | class = Serotonin 5-HT2A receptor antagonist | ATC_prefix = C02 | ATC_suffix = KD01 | ATC_supplemental =
Excerpted from Wikipedia’s “ketanserin” article, available under the CC BY-SA 4.0 licence.