Gene data
DUSP10- Name
- dual specificity phosphatase 10
- Type
- protein-coding
- Position
- 221,700,666–221,743,169 (−)
- Aliases
- MKP-5, MKP5
- Ensembl
- ENSG00000143507
- RefSeq RNA
- NM_007207.6, NM_144728.2, NM_144729.2, NR_111939.2, NR_111940.2
- RefSeq protein
- NP_009138.1, XP_016855636.1, XP_047298898.1, XP_047298904.1, XP_054189977.1
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].
Gene Ontology
Biological process
Molecular function
Pathways
MAPK signaling pathway - Homo sapiens (human)RAF-independent MAPK1/3 activationSignal TransductionDiseaseDiseases of signal transduction by growth factor receptors and second messengersRAF/MAP kinase cascadeNegative regulation of MAPK pathwayMAPK family signaling cascadesMAPK1/MAPK3 signalingOncogenic MAPK signaling
via MyGene.info